Results 41 to 50 of about 1,994 (199)

Comprehensive Analyses of the Strongly Carbon-chain Depleted Comets in Lowell Observatory’s Narrowband Photometry Database

open access: yesThe Planetary Science Journal
We present measurements, analyses, and results for the 17 strongly carbon-chain depleted comets in Lowell Observatory’s narrowband photometry database.
Allison N. Bair, David G. Schleicher
doaj   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng   +9 more
wiley   +1 more source

Svante Arrhenius, cosmical physicist and auroral theorist [PDF]

open access: yesHistory of Geo- and Space Sciences, 2013
Many scientists in the fin de siècle era saw a need to coordinate and unify the increasing amount of data relating the physical conditions of the Earth and the Sun; or more generally to establish a synthetic perspective that covered the earth sciences in
H. Kragh
doaj   +1 more source

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine

open access: yesAdvanced Science, EarlyView.
An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu   +8 more
wiley   +1 more source

Detection of OH Maser Emission in the 71 yr Periodic Comet 12P/Pons-Brooks Using the 40 m Thai National Radio Telescope

open access: yesThe Planetary Science Journal
Although the optical cometary database is extensive, the radio database is limited. The 18 cm OH maser observations of comets allow us to determine (i) the production rate of OH ( Q _OH ) and (ii) the water expansion velocity, for each comet.
Nobuyuki Sakai   +57 more
doaj   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji   +10 more
wiley   +1 more source

Free Energies of Reaction for Aqueous Glycine Condensation Chemistry at Extreme Temperatures

open access: yesGeophysical Monograph Series, Page 271-283., 2020

This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.

Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions

Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Matthew Kroonblawd, Nir Goldman
wiley  

+1 more source

Activity Analysis on 68P/Klemola and 78P/Gehrels 2 in 2018–2020 Perihelion Passage

open access: yesThe Astronomical Journal
We performed secular monitoring broadband photometric observations on Jupiter Family Comets (JFCs) 68P/Klemola and 78P/Gehrels 2 from 2018 November to 2020 March with the Yaoan High Precision Telescope.
Ruiqi Xu   +5 more
doaj   +1 more source

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

open access: yesAdvanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan   +8 more
wiley   +1 more source

Physical Observations of the Short-Period Comet 1969 IV [PDF]

open access: yesSymposium - International Astronomical Union, 1972
The new short-period comet Churyumov-Gerasimenko, discovered by the authors on plates taken by the Kiev University cometary expedition to Alma-Ata in September 1969, was systematically photographed with fast telescopes at Byurakan and Alma-Ata until March 1970.
K. I. Churyumov, S. I. Gerasimenko
openaire   +1 more source

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