Results 71 to 80 of about 6,463,650 (307)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Considering Pricing Problem in a Dynamic and Integrated Design of Sustainable Closed-loop Supply Chain Network

International Journal of Industrial Engineering and Production Research, 2016
Flexible and dynamic supply chain network design problem has been studied by many researchers during past years. Since integration of short-term and long-term decisions in strategic planning leads to more reliable plans, in this paper a multi-objective ...
Arash Nobari, Saman Kheirkhah, Maryam Esmaeili   +2 more
doaj  

A framework for product development based on recycled plastic from pesticide packaging: A study of short supply chains from the perspective of circular economy

Cleaner Production Letters
The global shift towards circular economies has emphasized the need to rethink traditional supply chains, particularly in industries with high waste outputs, like plastics.
Paschoal José de Pilla, Jr., Márcio Lopes Pimenta, Bruno Garcia de Oliveira   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Innovation in humanitarian logistics and supply chain management: a systematic review

, 2023
The COVID-19 global health crisis forced border closings, strained resources and tightened funding, forcing humanitarian organisations to innovate. This paper aims to identify gaps in the literature on innovation in humanitarian supply chains, and to ...
Heaslip, G, Vaillancourt, Alain, Tatham, P, Altay, N, Tatham, Peter, Kovács, G, Heaslip, Graham, Spens, K, Vaillancourt, A, Kovács, Gyöngyi, Altay, Nezih, Spens, Karen, Karen Spens, Nezih Altay, Gyöngyi Kovács, Graham Heaslip, Alain Vaillancourt, Peter Tatham   +17 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From bottlenecks to inflation: Impact of global supply-chain disruptions on inflation in select Asian economies

Latin American Journal of Central Banking
Supply-chain bottlenecks emerged alongside unprecedented inflationary surges amid the resulting mismatches in supply and demand for goods and services throughout the COVID-19 pandemic.
Reizle Jade C. Platitas, Jan Christopher G. Ocampo   +1 more
doaj   +1 more source

Logistic Challenges in the Short Food Supply Chains

Regional and Business Studies, 2020
The aim of the Paper is to identify the types of short food supply chains (SFSCs), their spread today, and to demonstrate the advantages or disadvantages they provide, especially the logistical problems and solutions that can be identified in the chain.
Szerb, András Bence, Horváth, Tamás, Szerb, Boglárka, Csonka, Arnold   +3 more
openaire   +3 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source