Results 81 to 90 of about 234,936 (321)

Short Tandem Repeats Information in TCGA is Statistically Biased by Amplification [PDF]

, 2019
The current paradigm in data science is based on the belief that given sufficient amounts of data, classifiers are likely to uncover the distinction between true and false hypotheses. In particular, the abundance of genomic data creates opportunities for
Bruck, Jehoshua, Jain, Siddharth, Mazaheri, Bijan, Raviv, Netanel   +3 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Short Tandem Repeats in Human Exons: A Target for Disease Mutations

BMC Genomics, 2008
Background In recent years it has been demonstrated that structural variations, such as indels (insertions and deletions), are common throughout the genome, but the implications of structural variations are still not clearly understood.
Villesen Palle, Madsen Bo, Wiuf Carsten
doaj   +1 more source

Detection and diversity of a putative novel heterogeneous polymorphic proline-glycine repeat (Pgr) protein in the footrot pathogen Dichelobacter nodosus [PDF]

, 2010
Dichelobacter nodosus, a Gram-negative anaerobic bacterium, is the essential causative agent of footrot in sheep. Currently, depending on the clinical presentation in the field, footrot is described as benign or virulent; D.
Atiya Ul-Hassan, Buller, Bzymek, Cheetham, Claire L. Russell, Claxton, Depiazzi, Elizabeth M.H. Wellington, Girard, Graham F. Medley, Gravekamp, Gravekamp, Heise, Hindmarsh, Jasmeet Kaler, Jelinek, Jordan, Julian I. Rood, Katz, Katz, Kay, Kennan, Kennan, La Fontaine, Ladefoged, Laura E. Green, Leo A. Calvo-Bado, Lukomski, Madoff, Moore, Myers, Nallapareddy, Nicky Buller, O’Dushlaine, Palmer, Paterson, Pringle, Puopolo, Rasmussen, Romero, Rood, Rose Grogono-Thomas, Ruth M. Kennan, Vanhoof, Verstrepen, Williamson, Yong, Zhang   +47 more
core   +4 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Massive variation of short tandem repeats with functional consequences across strains of Arabidopsis thaliana

bioRxiv, 2017
Short tandem repeat (STR) mutations may be responsible for more than half of the mutations in eukaryotic coding DNA, yet STR variation is rarely examined as a contributor to complex traits.
M. Press, R. McCoy, Ashley N. Hall, J. Akey, C. Queitsch   +4 more
semanticscholar   +1 more source

The motif composition of variable number tandem repeats impacts gene expression

bioRxiv, 2023
Understanding the impact of DNA variation on human traits is a fundamental question in human genetics. Variable number tandem repeats (VNTRs) make up roughly 3% of the human genome but are often excluded from association analysis due to poor read ...
Tsung-Yu Lu, Paulina N. Smaruj, G. Fudenberg, Nicholas Mancuso, Mark J. P. Chaisson   +4 more
semanticscholar   +1 more source

Assessing the Epigenetic Status of Human Telomeres [PDF]

, 2019
The epigenetic modifications of human telomeres play a relevant role in telomere functions and cell proliferation. Therefore, their study is becoming an issue of major interest.
Vaquero Sedas, María Isabel, Vega Palas, Miguel Ángel   +1 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Transcription as a Threat to Genome Integrity [PDF]

, 2016
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés, Gaillard, Hélène   +1 more
core   +1 more source