Results 51 to 60 of about 163,355 (309)
Вавиловский журнал генетики и селекции, 2018 Colorectal cancer (CRC) is one of the most common malignant neoplasms in the world, and is characterized by a high mortality rate. The study of the key aspects of colorectal cancer formation and progression is necessary to develop new approaches to its ...
M. S. Fedorova +11 more
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shRNA: solving the subtle [PDF]
Science-Business eXchange, 2008 Also in the RNA therapeutics space, a separate report in PNAS illustrates how subtle structural differences between artificial small hairpin RNA and endogenous microRNA may help explain the difference between shRNA having a therapeutic effect or being toxic.
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Expression of shRNA using intron splicing [PDF]
Nucleic Acids Symposium Series, 2007 RNA is considered a highly promising candidate for several applications such as gene knock-down, gene repair and gene therapy, where double-stranded RNA and RNA with catalytic activity are key players. A group I intron, a ribozyme catalyzing its own splicing reactions in the absence of any proteins, has generated interest for its potential utility in ...
Kousei, Noguchi +3 more
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Deep sequencing insights in therapeutic shRNA processing and siRNA target cleavage precision. [PDF]
, 2014 TT-034 (PF-05095808) is a recombinant adeno-associated virus serotype 8 (AAV8) agent expressing three short hairpin RNA (shRNA) pro-drugs that target the hepatitis C virus (HCV) RNA genome.
Nikki Carter +41 more
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Optimized models for design of efficient miR30-based shRNAs
Frontiers in Genetics, 2012 Small hairpin RNAs (shRNAs) became an important research tool in cell biology. Reliable design of these molecules is essential for the needs of large functional genomics projects.
Olga V Matveeva +4 more
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Down-regulation of perilipin 2 inhibits proliferation of human gastric cancer cell line NCI-N87 [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate the expression of perilipin 2 in gastric cancer and its effect on the proliferation, invasion and migration of cancer cells. Methods Human normal gastric mucosa cell line GES-1 and human gastric cancer cell line NCI-N87 were ...
LIU Lian-ling, LI Yong
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shRNA libraries and their use in cancer genetics [PDF]
Nature Methods, 2006 RNA interference was originally described as a powerful tool to inhibit gene expression in model organisms. Until recently, loss-of-function genetic screens in mammalian cells were hampered by a lack of suitable tools that can be used in a high-throughput format.
Bernards, R.A. +2 more
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EFNB2-shRNA-2_vs_Control_all_detectable_genes [PDF]
Bulk RNA-seq of RPMI-8226 Human Multiple Myeloma Cells with EFNB2 ...
Joshua Sasine (17745378)
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Cancer Management and Research, 2021 Beina Hui,1 Shupei Pan,2 Shaomin Che,1 Yuchen Sun,1 Yanli Yan,1 Jia Guo,1 Tuotuo Gong,1 Juan Ren,1 Xiaozhi Zhang1 1Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, 710061 ...
Hui B +8 more
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