Results 151 to 160 of about 1,450,984 (187)

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

open access: yesMedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

open access: yesNaval Research Logistics (NRL), Volume 73, Issue 7, Page 1141-1158, October 2026.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

Seizures in children with Dravet syndrome in extreme heat: A qualitative study of parental perspectives

open access: yesDevelopmental Medicine &Child Neurology, Volume 68, Issue 10, Page 1450-1459, October 2026.
Perspectives of parents of children with Dravet syndrome indicate that extreme heat and high temperatures exacerbate epileptic seizures, introduce new seizure triggers, and require the adoption of specific seizure‑management strategies. This original article is commented by Hood on pages 1338–1339 of this issue.
Angel Aledo‐Serrano   +8 more
wiley   +1 more source

The Role of Environmental Parameters in the Evolution of Holm Oak (Quercus ilex L. subsp. ballota (Desf.) Samp) Decline: Studies in the Iberian Peninsula

open access: yesForest Pathology, Volume 56, Issue 5, October 2026.
ABSTRACT The combination of geographical factors (climate, slope, orientation, lithology, water availability, etc.) and the pathogenicity of agents such as the oomycete from the kingdom Straminopile Phytophthora or Pythium species causes the plant disease known as oak decline in the Iberian Peninsula. Leaving aside the presence of the pathogen, the aim
Mario Corral Ribera   +2 more
wiley   +1 more source

Aflatoxin B1 triggers ferroptosis via inhibiting the NRF2 signaling pathway in duck granulosa cells. [PDF]

open access: yesPoult Sci
Chen Y   +11 more
europepmc   +1 more source

Exploring the significance of Kenya's indigenous and emerging blue foods for sustainable aquaculture development. A review

open access: yesJournal of the World Aquaculture Society, Volume 57, Issue 5, October 2026.
Abstract Kenya's aquaculture sector is at a pivotal stage, transitioning from a historical reliance on Nile tilapia and African catfish toward a more diversified production portfolio that integrates indigenous and emerging freshwater and marine species. This shift is increasingly recognized as essential to enhance climate resilience, food security, and
Jonathan Munguti   +9 more
wiley   +1 more source

Selenoprotein P Deficiency Is Associated with Early Signs of Kidney Disease and Hospitalization Risk in Heart Failure. [PDF]

open access: yesNutrients
Ohlsson MA   +9 more
europepmc   +1 more source

The miR167–ARF8 module coordinates stamen–pistil development and fruit set in tomato

open access: yesNew Phytologist, Volume 252, Issue 2, Page 647-665, October 2026.
SlMIR167a is the functionally prominent SlMIR167 gene in tomato fruit development. Summary Auxin is an important regulator of reproductive development. The families of the AUXIN RESPONSE FACTOR (ARF) genes, important components of the auxin signal, have expanded in flowering plants.
Nave Man   +7 more
wiley   +1 more source

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