Results 1 to 10 of about 113,461 (351)

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site [PDF]

Nature Communications, 2018
Sialic acid transporters (SiaT) are required for sialic acid uptake in a number of human pathogens and are of interest as targets for antimicrobial drug development. Here the authors present the substrate bound SiaT structure from the uropathogen Proteus
Weixiao Y. Wahlgren, Elin Dunevall, Rachel A. North, Aviv Paz, Mariafrancesca Scalise, Paola Bisignano, Johan Bengtsson-Palme, Parveen Goyal, Elin Claesson, Rhawnie Caing-Carlsson, Rebecka Andersson, Konstantinos Beis, Ulf J. Nilsson, Anne Farewell, Lorena Pochini, Cesare Indiveri, Michael Grabe, Renwick C. J. Dobson, Jeff Abramson, S. Ramaswamy, Rosmarie Friemann   +20 more
doaj   +4 more sources

SIAE-Mediated Loss of Sialic Acid Acetylation Contributes to Ulcerative Colitis [PDF]

Journal of Inflammation Research
Siyue Bo,1,* Xiaotong Wang,1– 3,* Jiani Qian,1,4 Guoqiang Ma,5 Zheng Ying,5 Duanmin Hu,2 Chunyan Hou,6 Junfeng Ma,6 Longjiang Xu,4 Shuang Yang1,7,8 1Center for Clinical Mass Spectrometry, College of Pharmaceutical Sciences, Soochow University ...
Bo S, Wang X, Qian J, Ma G, Ying Z, Hu D, Hou C, Ma J, Xu L, Yang S   +9 more
doaj   +2 more sources

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein [PDF]

Communications Biology
The tripartite ATP-independent periplasmic (TRAP) transporters enable Vibrio cholerae and Haemophilus influenzae to acquire sialic acid, aiding their colonization of human hosts.
Niels Schneberger, Philipp Hendricks, Martin F. Peter, Erik Gehrke, Sophie C. Binder, Paul-Albert Koenig, Stephan Menzel, Gavin H. Thomas, Gregor Hagelueken   +8 more
doaj   +2 more sources

Concentration and distribution of sialic acid in human milk and its correlation with dietary intake

Frontiers in Nutrition, 2022
PurposeThis study evaluates the content, distribution, and changing trend of sialic acid in human milk and the correlation between dietary intake of sialic acid and that in human milk.MethodsThe study included 33 mothers of full-term and exclusively ...
Qiaoling Xie, Yuhan Xu, Wei Zhang, Meizhen Zhu, Xinyue Wang, Jiale Huang, Yingying Zhuang, Hui Lan, Xiaoxuan Chen, Dongbei Guo, Hongwei Li   +10 more
doaj   +1 more source

Sialic acid utilisation and synthesis in the neonatal rat revisited. [PDF]

PLoS ONE, 2009
BACKGROUND:Milk is the sole source of nutrients for neonatal mammals and is generally considered to have co-evolved with the developmental needs of the suckling newborn.
Peter I Duncan, Frédéric Raymond, Andreas Fuerholz, Norbert Sprenger   +3 more
doaj   +1 more source

Relationship between plasma sialic acid and fibinogen concentration and incident micro-and macrovascular complications in type 1 diabetes [PDF]

, 2008
AIMS/HYPOTHESIS: Type 1 diabetes is associated with an increased risk of vascular complications. This increased risk could be explained by sialic acid and/or fibrinogen.
CHATURVEDI N, FULLER JH, MICCOLI, ROBERTO, On behalf of EURODIAB PCS STUDY GROUP, PICKUP JC, SOEDAMAH MUTHU SS   +5 more
core   +9 more sources

Usefulness of sialic acid for diagnosis of sepsis in critically ill patients: a retrospective study

BMC Anesthesiology, 2020
Background Early diagnosis of sepsis is very important. It is necessary to find effective and adequate biomarkers in order to diagnose sepsis. In this study, we compared the value of sialic acid and procalcitonin for diagnosing sepsis.
Bo Yao, Wen-juan Liu, Di Liu, Jin-yan Xing, Li-juan Zhang   +4 more
doaj   +1 more source

Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses

Viruses, 2022
Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2,3 and α-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species ...
Chuankuo Zhao, Juan Pu
doaj   +1 more source

Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size

iScience, 2022
Summary: The mucosal antiviral role of type I and III interferon in influenza virus infection is well established. However, much less is known about the antiviral mechanism of type II interferon (interferon-gamma).
Carol Ho-Yan Fong, Lu Lu, Lin-Lei Chen, Man-Lung Yeung, Anna Jinxia Zhang, Hanjun Zhao, Kwok-Yung Yuen, Kelvin Kai-Wang To   +7 more
doaj   +1 more source

The Identification of Sialuria with Different Degrees of Intellectual Disabilities in Children and Adolescents

Annals of Psychophysiology, 2021
Background: Single nucleotide polymorphism/mutation in the R263L region of the allosteric site of the GNE gene produces a phenotype with an overproduction of intracellular levels of sialic acid and causes sialuria.
Hina Ishtiaq, Sonia Siddiqui, Rukhsana Nawaz, Muhammad Ashraf Hussain, Fauzia Imtiaz, Zeba Haque   +5 more
doaj   +1 more source