Results 1 to 10 of about 5,135,061 (391)

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site [PDF]

Nature Communications, 2018
Sialic acid transporters (SiaT) are required for sialic acid uptake in a number of human pathogens and are of interest as targets for antimicrobial drug development. Here the authors present the substrate bound SiaT structure from the uropathogen Proteus
Weixiao Y. Wahlgren, Elin Dunevall, Rachel A. North, Aviv Paz, Mariafrancesca Scalise, Paola Bisignano, Johan Bengtsson-Palme, Parveen Goyal, Elin Claesson, Rhawnie Caing-Carlsson, Rebecka Andersson, Konstantinos Beis, Ulf J. Nilsson, Anne Farewell, Lorena Pochini, Cesare Indiveri, Michael Grabe, Renwick C. J. Dobson, Jeff Abramson, S. Ramaswamy, Rosmarie Friemann   +20 more
doaj   +5 more sources

Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses

Viruses, 2022
Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2,3 and α-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species ...
Chuankuo Zhao, Juan Pu
doaj   +2 more sources

Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics

Frontiers in Oncology, 2018
Metastatic breast cancer is currently incurable. It has recently emerged that different metabolic pathways support metastatic breast cancer. To further uncover metabolic pathways enabling breast cancer metastasis, we investigated metabolic differences in
Shao Thing Teoh, Martin P. Ogrodzinski, Martin P. Ogrodzinski, Christina Ross, Kent W. Hunter, Sophia Y. Lunt, Sophia Y. Lunt   +6 more
doaj   +2 more sources

Biological function of sialic acid and sialylation in human health and disease. [PDF]

Cell Death Discov
Sialic acids are predominantly found at the terminal ends of glycoproteins and glycolipids and play key roles in cellular communication and function. The process of sialylation, a form of post-translational modification, involves the covalent attachment ...
Zhu W, Zhou Y, Guo L, Feng S.
europepmc   +2 more sources

SIAE-Mediated Loss of Sialic Acid Acetylation Contributes to Ulcerative Colitis [PDF]

Journal of Inflammation Research
Siyue Bo,1,* Xiaotong Wang,1– 3,* Jiani Qian,1,4 Guoqiang Ma,5 Zheng Ying,5 Duanmin Hu,2 Chunyan Hou,6 Junfeng Ma,6 Longjiang Xu,4 Shuang Yang1,7,8 1Center for Clinical Mass Spectrometry, College of Pharmaceutical Sciences, Soochow University ...
Bo S, Wang X, Qian J, Ma G, Ying Z, Hu D, Hou C, Ma J, Xu L, Yang S   +9 more
doaj   +2 more sources

Relationship between dietary sialic acid intake and serum HbA1c: a population-based study in Xiamen, China [PDF]

Scientific Reports
This study investigates the correlation between dietary sialic acid intake which mainly come from eggs, red meat, and dairy products and serum HbA1c levels. A survey among Xiamen’s general population, China, collected dietary data from 2,908 participants
Zecheng Zhou, Wei Zhang, Xinyue Wang, Wanqiu Sha, Zhikun Xu, Hongwei Li, Jiale Huang   +6 more
doaj   +2 more sources

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein [PDF]

Communications Biology
The tripartite ATP-independent periplasmic (TRAP) transporters enable Vibrio cholerae and Haemophilus influenzae to acquire sialic acid, aiding their colonization of human hosts.
Niels Schneberger, Philipp Hendricks, Martin F. Peter, Erik Gehrke, Sophie C. Binder, Paul-Albert Koenig, Stephan Menzel, Gavin H. Thomas, Gregor Hagelueken   +8 more
doaj   +2 more sources

Concentration and distribution of sialic acid in human milk and its correlation with dietary intake

Frontiers in Nutrition, 2022
PurposeThis study evaluates the content, distribution, and changing trend of sialic acid in human milk and the correlation between dietary intake of sialic acid and that in human milk.MethodsThe study included 33 mothers of full-term and exclusively ...
Qiaoling Xie, Yuhan Xu, Wei Zhang, Meizhen Zhu, Xinyue Wang, Jiale Huang, Yingying Zhuang, Hui Lan, Xiaoxuan Chen, Dongbei Guo, Hongwei Li   +10 more
doaj   +1 more source

Targeting the Siglec–Sialic Acid Immune Axis in Cancer: Current and Future Approaches

Cancer immunology research, 2022
The sialic acid–binding immunoglobulin-like lectin (Siglec)–sialic acid immune axis is an evolutionarily conserved immunoregulatory pathway that provides a mechanism for establishing self-recognition and combatting invasive pathogens.
H. Läubli, Sam C. Nalle, D. Maslyar
semanticscholar   +1 more source

Sialic acid utilisation and synthesis in the neonatal rat revisited. [PDF]

PLoS ONE, 2009
BACKGROUND:Milk is the sole source of nutrients for neonatal mammals and is generally considered to have co-evolved with the developmental needs of the suckling newborn.
Peter I Duncan, Frédéric Raymond, Andreas Fuerholz, Norbert Sprenger   +3 more
doaj   +1 more source