Results 1 to 10 of about 5,225,006 (338)

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site [PDF]

Nature Communications, 2018
Sialic acid transporters (SiaT) are required for sialic acid uptake in a number of human pathogens and are of interest as targets for antimicrobial drug development. Here the authors present the substrate bound SiaT structure from the uropathogen Proteus
Weixiao Y. Wahlgren, Elin Dunevall, Rachel A. North, Aviv Paz, Mariafrancesca Scalise, Paola Bisignano, Johan Bengtsson-Palme, Parveen Goyal, Elin Claesson, Rhawnie Caing-Carlsson, Rebecka Andersson, Konstantinos Beis, Ulf J. Nilsson, Anne Farewell, Lorena Pochini, Cesare Indiveri, Michael Grabe, Renwick C. J. Dobson, Jeff Abramson, S. Ramaswamy, Rosmarie Friemann   +20 more
doaj   +5 more sources

Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses

Viruses, 2022
Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2,3 and α-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species ...
Chuankuo Zhao, Juan Pu
doaj   +2 more sources

Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives [PDF]

, 2017
Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases).
Andrew Bell, Angata, Bednarski, Chen, Chokhawala, Chokhawala, Crost, Crost, Dimitrios Latousakis, Etzold, Furuhata, Gerardy-Schahn, Gwenaelle Le Gall, Hai Yu, Ian J. Colquhoun, Juge, Juge, Lee, Lewis, Li, Li, Lifely, Louise E. Tailford, Luo, Luo, Marie Monestier, Martin Rejzek, Nathalie Juge, Ouwerkerk, Robert A. Field, Rohrer, Sandra Tribolo, Savage, Schauer, Schroder, Simone Dedola, Suzuki, Tailford, Tailford, Varki, Xi Chen, Yu   +41 more
core   +4 more sources

Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics

Frontiers in Oncology, 2018
Metastatic breast cancer is currently incurable. It has recently emerged that different metabolic pathways support metastatic breast cancer. To further uncover metabolic pathways enabling breast cancer metastasis, we investigated metabolic differences in
Shao Thing Teoh, Martin P. Ogrodzinski, Martin P. Ogrodzinski, Christina Ross, Kent W. Hunter, Sophia Y. Lunt, Sophia Y. Lunt   +6 more
doaj   +2 more sources

Predictive Value of Serum Sialic Acid in Type-2 Diabetes Mellitus and Its Complication (Nephropathy) [PDF]

Journal of Clinical and Diagnostic Research, 2013
Introduction: Sialic acid levels are increased in type-2 diabetes mellitus and its estimation helps in predicting the occurrence of microvascular complication such as diabetic nephropathy. The present study compared the levels of sialic acid, glycated
Prajna K., Ashok Kumar J., Srinidhi Rai, Shobith Kumar Shetty, Tirthal Rai, Shrinidhi, Mohamedi Begum, Shashikala MD   +7 more
doaj   +2 more sources

Comparison of serum and bronchoalveolar lavage fluid sialic acid levels between malignant and benign lung diseases [PDF]

BMC Pulmonary Medicine, 2001
Background It is known that tissue and serum sialic acid levels may be altered by malignant transformation. In this study, sialic acid levels were determined in bronchoalveolar lavage fluid (BAL) and serum in two groups of patients with lung cancer and ...
Aydilek Recep, Budak Yasemin, Isitmangil Gulbu, Isitmangil Turgut, Celenk Mehmet   +4 more
doaj   +2 more sources

Biological function of sialic acid and sialylation in human health and disease. [PDF]

Cell Death Discov
Sialic acids are predominantly found at the terminal ends of glycoproteins and glycolipids and play key roles in cellular communication and function. The process of sialylation, a form of post-translational modification, involves the covalent attachment ...
Zhu W, Zhou Y, Guo L, Feng S.
europepmc   +2 more sources

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis. [PDF]

J Immunother Cancer
O'Neill A, Zakaria N, Bull C, Egan H, Corry SM, Leonard NA, O'Meara C, Howard L, Walsh A, Reidy E, Che J, Peng L, Cao L, Egan LJ, Ritter T, Sheehan M, Canney A, Culligan K, Hogan AM, Hynes SO, Dunne PD, O'Dwyer M, Treacy O, Ryan AE.   +23 more
europepmc   +2 more sources

SIAE-Mediated Loss of Sialic Acid Acetylation Contributes to Ulcerative Colitis [PDF]

Journal of Inflammation Research
Siyue Bo,1,* Xiaotong Wang,1– 3,* Jiani Qian,1,4 Guoqiang Ma,5 Zheng Ying,5 Duanmin Hu,2 Chunyan Hou,6 Junfeng Ma,6 Longjiang Xu,4 Shuang Yang1,7,8 1Center for Clinical Mass Spectrometry, College of Pharmaceutical Sciences, Soochow University ...
Bo S, Wang X, Qian J, Ma G, Ying Z, Hu D, Hou C, Ma J, Xu L, Yang S   +9 more
doaj   +2 more sources

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein [PDF]

Communications Biology
The tripartite ATP-independent periplasmic (TRAP) transporters enable Vibrio cholerae and Haemophilus influenzae to acquire sialic acid, aiding their colonization of human hosts.
Niels Schneberger, Philipp Hendricks, Martin F. Peter, Erik Gehrke, Sophie C. Binder, Paul-Albert Koenig, Stephan Menzel, Gavin H. Thomas, Gregor Hagelueken   +8 more
doaj   +2 more sources