Unraveling the Differences of the Hydrolytic Activity of Trypanosoma cruzi trans-Sialidase and Trypanosoma rangeli Sialidase: A Quantum Mechanics–Molecular Mechanics Modeling Study [PDF]
, 2014 Chagas’ disease, also known as American trypanosomiasis, is a lethal, chronic disease that currently affects more than 10 million people in Central and South America. The trans-sialidase from Trypanosoma cruzi (T. cruzi, TcTS) is a crucial enzyme for the
Bueren Calabuig, Juan A. +2 more
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Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Free and bound forms of sialic acid in blood plasma of patients with chronic lymphocytic leukemia
Regulatory Mechanisms in Biosystems, 2015 The level of free and bound forms of sialic acids (SА) was investigated in chronic lymphocytic leukemia (CLL) and at different stages of receiving chemotherapy.
O. V. Netronina
doaj +1 more source
Implication of Sialidases in Salmonella Infection: Genome Release of Sialidase Knockout Strains from Salmonella enterica Serovar Typhimurium LT2. [PDF]
, 2017 Sialidases, which are widely distributed in nature, cleave the α-ketosidic bond of terminal sialic acid residue. These emerging virulence factors degrade the host glycan.
Arabyan, Narine +3 more
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The Effect of Sialic Acid on MiR-320a and Let-7e Expression in Human Glial Cell Line
Basic and Clinical Neuroscience, 2022 Introduction: Sialic acid is pivotal in various critical physiological events at molecular and cellular levels and pathological processes. Changes in sialic acid concentration are observed in many pathological processes; for example, some available data ...
Negar Noorbakhsh +2 more
doaj
Predictive Value of Serum Sialic Acid in Type-2 Diabetes Mellitus and Its Complication (Nephropathy) [PDF]
Journal of Clinical and Diagnostic Research, 2013 Introduction: Sialic acid levels are increased in type-2 diabetes mellitus and its estimation helps in predicting the occurrence of microvascular complication such as diabetic nephropathy. The present study compared the levels of sialic acid, glycated
Prajna K. +7 more
doaj +1 more source
Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition [PDF]
, 2013 The recognition of sialic acids by two strains of minute virus of mice (MVM), MVMp (prototype) and MVMi (immunosuppressive), is an essential requirement for successful infection.
Agbandje-McKenna, M +12 more
core +1 more source
N-acetylneuraminic acid: A scrutinizing tool in oral squamous cell carcinoma diagnosis
Dental Research Journal, 2017 Background: Oral cancer has one of the highest mortality rate among other malignancies. An attempt has been made to assess the genetic expression of a cell surface glycoprotein component - sialic acid released by the malignant cells which will reflect on
Suganya Rajaram +4 more
doaj +1 more source
Sialic acids in gastropods [PDF]
FEBS Letters, 2001 The occurrence of N‐acetylneuraminic acid and N‐glycolylneuraminic acid residues in preparations of the slug Arion lusitanicus (Gastropoda) was determined by sodium dodecyl sulphate electrophoresis of the proteins followed by lectin blots stained with the sialic acid specific lectin from Maackia amurensis, by the sensitivity of this binding to ...
Bürgmayr, Sabine +2 more
openaire +2 more sources
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
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