Results 61 to 70 of about 2,579,458 (259)

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs [PDF]

, 2019
Contains fulltext : 207220pub.pdf (Publisher’s version ) (Open Access) Contains fulltext : 207220po.pdf (Author’s version postprint ) (Open Access)Sialic acids cap the glycans of cell
Derks, M.T., Adema, G.J., Boltje, T.J., Büll, C., Büll, C., Moons, S.J.   +5 more
core   +1 more source

Efficient TurboID-based proximity labelling method for identifying terminal sialic acid glycosylation in living cells

Acta Biochimica et Biophysica Sinica, 2022
TurboID, a proximity labelling method based on mutant biotin ligase, is an efficient new technique for recognizing protein-protein interactions and has been successfully applied to living cells.
Liu Wu, Long Yunfeng, Bao Yongfen, Li Yang, Deng Mengxue, Yang Xiuyi, Zhu He, Su Yanting   +7 more
doaj   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Evaluation of salivary sialic acid and salivary Alpha-L-Fucosidase levels in patients with oral submucous fibrosis- A cross-sectional study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Saliva, a non-invasive diagnostic tool, is used to evaluate sialic acid and Alpha-L-Fucosidase in OSMF. Sialylation and fucosylation are glycosylation changes that mediate vital biological functions.
Sunaina Swatantramath, Daya K Jangam, Kajol Talreja, Pranali Bahadure, Antara Kore   +4 more
doaj   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Structures of B-lymphotropic polyomavirus VP1 in complex with oligosaccharide ligands. [PDF]

PLoS Pathogens, 2013
B-Lymphotropic Polyomavirus (LPyV) serves as a paradigm of virus receptor binding and tropism, and is the closest relative of the recently discovered Human Polyomavirus 9 (HPyV9).
Ursula Neu, Zaigham Mahmood Khan, Benjamin Schuch, Angelina S Palma, Yan Liu, Michael Pawlita, Ten Feizi, Thilo Stehle   +7 more
doaj   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Structural Insight into the Bacterial Sialic Acid Catabolic Pathway [PDF]

, 2018
A genetically diverse community of commensal and pathogenic bacteria thrive in the digestive system and urogenital tracts of animals. Many of these bacteria forage sialic acid from mucosal cell surfaces.
Caing-Carlsson, Rhawnie
core   +1 more source

The Effect of Sialic Acid on Viability and Growth of Mice Astrocytes and Human Astroglia Cells

مجله دانشکده پزشکی اصفهان, 2018
Background: The surface of all vertebrate cells is covered with sugar chains like sialic acid that are found at high levels in sialoglycan form in vertebrate brain.
Maryam Cheraghzadeh, Shirin Azizidoost, Zahra Nazeri, Sadegh Saremi, Hamid Galehdari, Alireza Kheirollah   +5 more
doaj   +1 more source