Results 71 to 80 of about 2,579,458 (259)

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

open access: yesAdvanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang   +6 more
wiley   +1 more source

Sialic-Acid-Anchored Micelles: A Hierarchical Targeting Device for Enhanced Tumor Tissue Accumulation and Cellular Internalization

open access: yes, 2018
Targeted drug delivery systems (TDDS) have attracted wide attention for their reduced drug side effects and improved antitumor efficacy in comparison with traditional preparations.
Meng-Lu Zhu   +17 more
core   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang   +9 more
wiley   +1 more source

Synthesis of antagonists of Myelin-associated glycoprotein (MAG) for conformational and SAR studies [PDF]

open access: yes, 2004
Damage to the central nervous system (CNS) of higher vertebrates, including humans, often results in devastating and persistent functional deficits.
Gao, Gan-Pan
core   +1 more source

Effects of sialic acid from edible bird nest on cell viability associated with brain cognitive performance in mice

open access: yesWorld Journal of Traditional Chinese Medicine, 2019
Background: Edible bird nest (EBN) is a natural food product rich in glycoprotein such as sialic acid, which has been reported to improve brain functions.
Siti Khadijah Abdul Khalid   +3 more
doaj   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

open access: yesAdvanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li   +9 more
wiley   +1 more source

Chemoenzymatic preparation of 4-O-acetyl sialic acid derivative

open access: yes, 2009
4-O-Acetyl sialic acid derivative could be easily prepared from the hydrolysis of 1 by lipase OF via the migration of acetyl groups ...
施增廉; Shih, Tzenge-lien; Chen, M. C.; Wu, S. H.
core   +1 more source

A Glycal-Based Photoaffinity Probe That Enriches Sialic Acid Binding Proteins [PDF]

open access: yes, 2019
To identify sialic acid binding proteins from complex proteomes, three photocrosslinking affinity-based probes were constructed using Neu5Ac (5 and 6) and Neu5Ac2en (7) scaffolds.
Peter, Thuy-Boun, Dennis, Wolan
core   +2 more sources

Relationship between dietary sialic acid intake and serum HbA1c: a population-based study in Xiamen, China

open access: yesScientific Reports
This study investigates the correlation between dietary sialic acid intake which mainly come from eggs, red meat, and dairy products and serum HbA1c levels. A survey among Xiamen’s general population, China, collected dietary data from 2,908 participants
Zecheng Zhou   +6 more
doaj   +1 more source

Preferential lectin binding of cancer cells upon sialic acid treatment under nutrient deprivation.

open access: yes, 2013
The terminal monosaccharide of glycoconjugates on a eukaryotic cell surface is typically a sialic acid (Neu5Ac). Increased sialylation usually indicates progression and poor prognosis of most carcinomas. Here, we utilize two human mammary epithelial cell
Djansugurova, L.B.   +5 more
core   +1 more source

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