Results 51 to 60 of about 2,579,458 (259)

Evaluation of N-Acetylmannosamine Administration to Restore Sialylation in GNE-Deficient Human Embryonal Kidney Cells

Frontiers in Bioscience-Landmark, 2023
Background: A key mechanism in the neuromuscular disease GNE myopathy (GNEM) is believed to be that point mutations in the GNE gene impair sialic acid synthesis – maybe due to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) activity ...
Emilia Peters, Philipp Selke, Kaya Bork, Rüdiger Horstkorte, Astrid Gesper   +4 more
doaj   +1 more source

Carbohydrate‐Directed Labeling Probes for UV‐Independent Chemoproteomic Profiling of Carbohydrate–Protein Interactions

Angewandte Chemie, EarlyView.
Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo, Wariya Nirachonkul, Nora Ross, Rahul M. Hedau, Zachary Clark, Michaella J. Rekowski, Michael P. Washburn, Mark P. Farrell   +7 more
wiley   +2 more sources

Estimation of Serum and Salivary Sialic Acid Level in Patients with Oral Squamous Cell Carcinoma

Journal of College of Medical Sciences-Nepal, 2019
Background: Sialic acid is a glycoprotein that is considered as an important constituent of cell membrane. Altered glycosylation is one of the important molecular changes that accompany malignant transformation.
Pratibha Poudel, Barsha Bajracharya, Shubrato Bhattacharyya, Dipshikha Bajracharya   +3 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Synthesis of bone meal-derived 4-carboxyphenylboronic acid functionalized sulfur and nitrogen co-doped graphene quantum dots nanoprobe for sialic acid sensing

Acta Chimica Slovenica
Detecting sialic acid using sensor-based technology in milk-based products is crucial. Therefore, present work reported the sulfur and nitrogen-doped graphene quantum dots from bone meal functionalized with boronic acid (Boro-S/N-dGQDs) nanoprobe for ...
Sopan Nangare, Pratik Yeole, Zamir Khan, Ashwini Patil, Bhushankumar Sathe, Sanjaykumar Bari, Pravin Onkar Patil   +6 more
doaj   +1 more source

Evaluation of Sialic Acid Levels in the Umbilical Cord Blood of Newborns of Diabetic and Non-Diabetic Mothers and the Relation with Poor Neonatal Outcome

Gynecology Obstetrics & Reproductive Medicine, 2021
Objective: The aim of this study is to evaluate sialic acid levels in cord blood samples of infants of natal diabetic and non-diabetic pregnancies and to assess the correlation of sialic acid levels with the poor neonatal outcomes.
Yuksel Kurban, İbrahim Uyar, Koza Murat, Murat Alan   +3 more
doaj   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli [PDF]

, 2012
NanC is an Escherichia coli outer membrane protein involved in sialic acid (Neu5Ac, i.e., N-acetylneuraminic acid) uptake. Expression of the NanC gene is induced and controlled by Neu5Ac. The transport mechanism of Neu5Ac is not known.
Peneff, Caroline M., Giri, Janhavi, Tang, John M., Eisenberg, Bob, Wirth, Christophe   +4 more
core   +1 more source

Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]

PLoS ONE, 2012
Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez, Isabel García-Álvarez, Ramón Campos-Olivas, Michel Gilbert, Marie-France Goneau, Alfonso Fernández-Mayoralas, Manuel Nieto-Sampedro   +6 more
doaj   +1 more source