Results 91 to 100 of about 70,452 (316)

Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]

arXiv, 2023
Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv  

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

Advanced Science, EarlyView.
The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec‐7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A combination of structural biology techniques, nuclear magnetic resonance (NMR) spectroscopy, physicochemical analysis, and in silico methods suggested that ...
Cristina Di Carluccio, Luis Padilla‐Cortés, Marta Tiemblo‐Martìn, Giulia Roxana Gheorghita, Rosario Oliva, Linda Cerofolini, Alessandro Antonio Masi, Celeste Abreu, Hsin‐Kai Tseng, Antonio Molinaro, Pompea Del Vecchio, Ondřej Vaněk, Chun‐Cheng Lin, Roberta Marchetti, Marco Fragai, Alba Silipo   +15 more
wiley   +1 more source

Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages. [PDF]

, 2019
Many bacterial pathogens hijack macrophages to egress from the port of entry to the lymphatic drainage and/or bloodstream, causing dissemination of life-threatening infections. However, the underlying mechanisms are not well understood.
Ferreira, Fernando, Guo, Betty P, Lebrilla, Carlito B, Lokken, Kristen L, Luxardi, Guillaume, Ma, Li, Maverakis, Emanual, Mogilner, Alex, Reid, Brian, Ryzhuk, Volodymyr, Sun, Yaohui, Sun, Yuxin, Xu, Gege, Zhao, Min, Zhu, Kan   +14 more
core   +2 more sources

Analysis of the changes in expression levels of sialic acid on influenza-virus-infected cells using lectin-tagged polymeric nanoparticles

Frontiers in Microbiology, 2016
Viral infections affect millions around the world, sometimes leading to severe consequences or even epidemics. Understanding the molecular dynamics during viral infections would provide crucial information for preventing or stopping the progress of ...
Jaebum Cho, Yukari Miyake, Ayae Honda, Keiichiro Kushiro, Madoka Takai   +4 more
doaj   +1 more source

A Reversible and Dynamic Surface Functionalization for Fluidity Controlled Multivalent Recognition of Lectins and Bacteria

Advanced Science, EarlyView.
A reversible wet chemical surface functionalization results in dynamic multivalent receptors showing ligand‐specific high affinity for lectins and bacteria. Abstract The paper reports the design of multivalent bacterial receptors based on reversible self‐assembled monolayers (rSAMs) on gold and glass substrates, mimicking the ligand display on host ...
Thomas Hix‐Janssens, Adam Tillo, Hanna Isaieva, Zita Lopes da Silva, Zahra Fatahi, Michele Larocca, Gustav Sedelius, Sara Björk Sigurdardóttir, Yulia Sergeeva, Tiba Al‐Dujaili, Julia R. Davies, Kushagr Punyani, Börje Sellergren   +12 more
wiley   +1 more source

Sialic Acid Mutarotation Is Catalyzed by the Escherichia coli β-Propeller Protein YjhT [PDF]

, 2008
The acquisition of host-derived sialic acid is an important virulence factor for some bacterial pathogens, but in vivo this sugar acid is sequestered in sialoconjugates as the {alpha}-anomer.
Leech, Andrew, Müller, Axel, Potts, Jennifer R., Severi, Emmanuele, Thomas, Gavin H., Williamson, David, Wilson, Keith S.   +6 more
core   +1 more source

Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli [PDF]

, 2012
NanC is an Escherichia coli outer membrane protein involved in sialic acid (Neu5Ac, i.e., N-acetylneuraminic acid) uptake. Expression of the NanC gene is induced and controlled by Neu5Ac. The transport mechanism of Neu5Ac is not known.
Eisenberg, Bob, Giri, Janhavi, Peneff, Caroline M., Tang, John M., Wirth, Christophe   +4 more
core   +1 more source

Sialic acids, sialoconjugates and enzymes of their metabolism in fungi

Biotechnology & Biotechnological Equipment, 2021
Sialic acids (Sia) represent a set of derivatives of nine-carbon sugar neuraminic acid that occupy a terminal position in oligosaccharide chains located on the surface of cells. They are very important for several physiological and pathological processes,
Rumyana Eneva, Stephan Engibarov, Radoslav Abrashev, Ekaterina Krumova, Maria Angelova   +4 more
doaj   +1 more source

Punctuated evolution of influenza virus hemagglutinin (A/H1N1) under opposing migration and vaccination pressures [PDF]

arXiv, 2012
Influenza virus contains two highly variable envelope glycoproteins, hemagglutinin (HA) and neuraminidase (NA). The structure and properties of HA, which is responsible for binding the virus to the cell that is being infected, change significantly when the virus is transmitted from avian or swine species to humans. Previously we identified much smaller
arxiv  

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source