Results 71 to 80 of about 70,786 (313)

Interventional Effects of Edible Bird's Nest or Sialic Acids on Sepsis-Induced Immunosuppression in Mice. [PDF]

Food Sci Nutr
This study reveals that edible bird's nest (EBN) and sialic acid (SA) efectively reverse sepsis‐induced immunosuppression. EBN and SA enhance T cell proliferation via the activation of the mTOR signaling pathway, and this enhanced proliferation mediates the protective effect.
Li S, Jiang Y, Wang K, Li H, Li J, Huang J, Wang J, Zhou L, Xie Y, Liu Y.   +9 more
europepmc   +2 more sources

Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans-An Evolutionary Perspective. [PDF]

, 2019
The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Altman, Meghan O, Gagneux, Pascal
core   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]

PLoS ONE, 2012
Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez, Isabel García-Álvarez, Ramón Campos-Olivas, Michel Gilbert, Marie-France Goneau, Alfonso Fernández-Mayoralas, Manuel Nieto-Sampedro   +6 more
doaj   +1 more source

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells [PDF]

, 2015
Sialic acids are negatively charged nine-carbon carboxylated monosaccharides that often cap glycans on glycosylated proteins and lipids. Because of their strategic location at the cell surface, sialic acids contribute to interactions that are critical ...
Hakan Kalay, Henrike Veninga, Janneke N. Samsom, Joke M. M. den Haan, Juan J. Garcia-Vallejo, Juan M. Ilarregui, Lenneke A. M. Cornelissen, Lisette A. van Berkel, Luciana Berod, Marleen I. Verstege, Martino Ambrosini, Maurizio Perdicchio, Paul R. Crocker, Sakaguchi, Sjoerd T. T. Schetters, Steef Engels, Tim Sparwasser, Wendy W. J. Unger, Yvette van Kooyk   +18 more
core   +4 more sources

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Sialic Acids in Health and Disease

Biologics
Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers.
Gerardo N. Guerrero-Flores, Fayth M. Butler, Veronica L. Martinez Marignac, Guangyu Zhang, Fabio J. Pacheco, Danilo S. Boskovic   +5 more
doaj   +1 more source

Sialic acid accelerates the electrophoretic velocity of injured dorsal root ganglion neurons

Neural Regeneration Research, 2015
Peripheral nerve injury has been shown to result in ectopic spontaneous discharges on soma and injured sites of sensory neurons, thereby inducing neuropathic pain.
Chen-xu Li, Guo-ying Ma, Min-fang Guo, Ying Liu   +3 more
doaj   +1 more source

Carbohydrates great and small, from dietary fiber to sialic acids: How glycans influence the gut microbiome and affect human health

Gut Microbes, 2021
Gut microbiome composition depends heavily upon diet and has strong ties to human health. Dietary carbohydrates shape the gut microbiome by providing a potent nutrient source for particular microbes.
Joanna K Coker, Oriane Moyne, Dmitry A. Rodionov, Karsten Zengler   +3 more
doaj   +1 more source