Results 101 to 110 of about 70,452 (316)
Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans-An Evolutionary Perspective. [PDF]
, 2019 The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Altman, Meghan O, Gagneux, Pascal
core +1 more source
Synthesis of partially O-acetylated N-acetylneuraminic acid using regioselective silyl exchange technology. [PDF]
, 2014 Postglycosylation acetylation of sialic acid imparts unique roles to sialoglycoconjugates in mammalian immune response making structural and functional understanding of these analogues important.
Gervay-Hague, Jacquelyn, Park, Simon S
core +2 more sources
Study of Selectivity and Permeation In Voltage-Gated Ion Channels [PDF]
arXiv, 2012 Ion channels are membrane proteins responsible for an enormous range of biological functions. Ion selectivity and permeation are based on simple laws of physics and chemistry. Ion channels are therefore ideal candidates for physical investigation. A reduced model generates the selectivity of voltage-gated L-type calcium channel under a wide range of ...
arxiv
Sialic acid on avian erythrocytes
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2019 Understanding variation in physiological traits across taxa is a central question in evolutionary biology that has wide-ranging implications in biomedicine, disease ecology, and environmental protection. Sialic acid (Sia), and in particular, 5-N-acetylneuraminic acid (Neu5Ac), is chemically bound to galactose and the underlying glycan via α2-3 or α2-6 ...
Mark D. Jankowski +5 more
openaire +2 more sources
Recent Advances in Xenes Based FET for Biosensing Applications
Advanced Science, EarlyView.Xenes (monoelemental 2D materials like graphene, phosphorene, tellurene) enable ultrasensitive FET (Field‐Effect Transistor) biosensors due to their tunable bandgap, high carrier mobility, and large surface area. Advances in synthesis (CVD, MBE) and functionalization allow detection of DNA/RNA (via CRISPR‐Cas systems), proteins, small molecules, and ...
Huide Wang +9 more
wiley +1 more source
Punctuated evolution of influenza virus neuraminidase (A/H1N1) under migration and vaccination pressures [PDF]
arXiv, 2012 Influenza virus contains two highly variable envelope glycoproteins, hemagglutinin (HA) and neuraminidase (NA). The structure and properties of HA, which is responsible for binding the virus to the cell that is being infected, change significantly when the virus is transmitted from avian or swine species to humans.
arxiv
Nature's Starships. I. Observed Abundances and Relative Frequencies of Amino Acids in Meteorites [PDF]
, 2014 The class of meteorites called carbonaceous chondrites are examples of material from the solar system which have been relatively unchanged from the time of their initial formation. These meteorites have been classified according to the temperatures and physical conditions of their parent planetesimals.
arxiv +1 more source
Advanced Science, EarlyView.Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou +17 more
wiley +1 more source
Prediction of specific virus outbreaks made from the increased concentration of a new class of virus genomic peptides, replikins. [PDF]
, 2011 Advance warning of pathogen outbreaks has not been possible heretofore. A new class of genomic peptides associated with rapid replication was discovered and named replikins. Software was designed to analyze replikins quantitatively.
Elenore S. Bogoch, Samuel Bogoch
core +2 more sources
Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs
Frontiers in Immunology, 2018 Sialic acids, a group of acidic sugars abundantly expressed in the tissues of deuterostome animals but rarely found in microbes, serve as a “signature of self” for these animals. Cognate sensors for sialic acids include Siglecs, a family of transmembrane
Takashi Angata
doaj +1 more source