Results 71 to 80 of about 70,452 (316)
Cloning of hemagglutinin (HA) protein of influenza A virus - Potential for sialic acid linkage discrimination [PDF]
, 2007 The initial step in infection of a cell by influenza A virus is the attachment of a virus particle to the target cell. This is accomplished by interaction of a glycoprotein, hemagglutinin (HA), found on the surface of the viral lipid membrane with cell ...
O'Connor, Brendan, Szczepaniak, Jakub
core
Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor [PDF]
, 2015 This research was supported by the University of St Andrews and grants provided by the Medical Research Council.Background: Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface.
Connaris, Helen +3 more
core +1 more source
Cellular & Molecular Biology LettersBackground Small extracellular vesicles (sEV) are closely associated with the development and metastasis of many types of mammalian cancer. Glycoconjugates are highly expressed on sEV and play important roles in sEV biogenesis and their interaction with ...
Meixuan Lin +11 more
doaj +1 more source
Sialic acid accelerates the electrophoretic velocity of injured dorsal root ganglion neurons
Neural Regeneration Research, 2015 Peripheral nerve injury has been shown to result in ectopic spontaneous discharges on soma and injured sites of sensory neurons, thereby inducing neuropathic pain.
Chen-xu Li +3 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: A key mechanism in the neuromuscular disease GNE myopathy (GNEM) is believed to be that point mutations in the GNE gene impair sialic acid synthesis – maybe due to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) activity ...
Emilia Peters +4 more
doaj +1 more source
Mucin-inspired, high molecular weight virus binding inhibitors show biphasic binding behavior to influenza A viruses [PDF]
arXiv, 2020 Multivalent virus binding inhibitors are a promising new class of antivirals, preventing virus infection of cells by inhibiting the first step in the viral infection cycle - binding of viruses to the cell surface. The design of multivalent virus binding inhibitors is complex as many properties, such as inhibitor size and functionalization with virus ...
arxiv
AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
Advanced Science, EarlyView.Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu +8 more
wiley +1 more source
Advanced Science, EarlyView.LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li +8 more
wiley +1 more source
Angewandte Chemie, EarlyView.Tetrazine precursors (SiaTz) based on a nonO‐acetylated sialic acid scaffold are rationally designed and synthesized, which can be efficiently converted into unnatural tetrazine (Tz) triggers on cancer cell surfaces via metabolic glycoengineering. These Tz triggers activate theranostic agents for multispectral optoacoustic tomographic (MSOT) imaging ...
Yinglong Wu +15 more
wiley +2 more sources
DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety [PDF]
, 1991 We have previously demonstrated that transferrin-polycation conjugates are efficient carrier molecules for the introduction of genes into eucariotic cells.
Birnstiel, Max L. +4 more
core +1 more source