Results 71 to 80 of about 69,641 (328)

Sialic Acid Mutarotation Is Catalyzed by the Escherichia coli β-Propeller Protein YjhT [PDF]

, 2008
The acquisition of host-derived sialic acid is an important virulence factor for some bacterial pathogens, but in vivo this sugar acid is sequestered in sialoconjugates as the {alpha}-anomer.
Leech, Andrew, Müller, Axel, Potts, Jennifer R., Severi, Emmanuele, Thomas, Gavin H., Williamson, David, Wilson, Keith S.   +6 more
core   +1 more source

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source

Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs

Glycobiology, 2019
Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes and aberrant sialic acid expression is associated with several pathologies. Sialic acids modulate the characteristics and functions of glycoproteins and regulate cell-cell as well as cell-extracellular matrix interactions.
Sam J Moons, Gosse J Adema, Max TGM Derks, Thomas J Boltje, Christian Büll   +4 more
openaire   +4 more sources

Sialic Acid Receptors of Viruses [PDF]

, 2013
Sialic acid linked to glycoproteins and gangliosides is used by many viruses as a receptor for cell entry. These viruses include important human and animal pathogens, such as influenza, parainfluenza, mumps, corona, noro, rota, and DNA tumor viruses.
Georg Herrler, Mikhail Matrosovich, Hans-Dieter Klenk   +2 more
openaire   +3 more sources

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells

Cellular & Molecular Biology Letters
Background Small extracellular vesicles (sEV) are closely associated with the development and metastasis of many types of mammalian cancer. Glycoconjugates are highly expressed on sEV and play important roles in sEV biogenesis and their interaction with ...
Meixuan Lin, Xiaoqiang Xu, Xiaoman Zhou, Hui Feng, Ruili Wang, Yunyun Yang, Jing Li, Ning Fan, Yazhuo Jiang, Xiang Li, Feng Guan, Zengqi Tan   +11 more
doaj   +1 more source

Sialidase NEU1 suppresses progression of human bladder cancer cells by inhibiting fibronectin-integrin α5β1 interaction and Akt signaling pathway

Cell Communication and Signaling, 2020
Background Sialic acids are widely distributed in animal tissues, and aberrantly expressed in a variety of cancer types. High expression of sialic acid contributes to tumor aggressiveness by promoting cell proliferation, migration, angiogenesis, and ...
Xiaoman Zhou, Yanhong Zhai, Changmei Liu, Ganglong Yang, Jia Guo, Guang Li, Chengwen Sun, Xiaowei Qi, Xiang Li, Feng Guan   +9 more
doaj   +1 more source

Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]

PLoS ONE, 2012
Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez, Isabel García-Álvarez, Ramón Campos-Olivas, Michel Gilbert, Marie-France Goneau, Alfonso Fernández-Mayoralas, Manuel Nieto-Sampedro   +6 more
doaj   +1 more source

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. [PDF]

, 2018
Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface.
Haigh, Nathan E, Lebrilla, Carlito B, Liu, Mingqi, Maverakis, Emanual, Park, Diane Dayoung, Phoomak, Chatchai, Wong, Maurice, Wongkham, Sopit, Xu, Gege, Yang, Pengyuan   +9 more
core  

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells [PDF]

, 2015
Sialic acids are negatively charged nine-carbon carboxylated monosaccharides that often cap glycans on glycosylated proteins and lipids. Because of their strategic location at the cell surface, sialic acids contribute to interactions that are critical ...
Hakan Kalay, Henrike Veninga, Janneke N. Samsom, Joke M. M. den Haan, Juan J. Garcia-Vallejo, Juan M. Ilarregui, Lenneke A. M. Cornelissen, Lisette A. van Berkel, Luciana Berod, Marleen I. Verstege, Martino Ambrosini, Maurizio Perdicchio, Paul R. Crocker, Sakaguchi, Sjoerd T. T. Schetters, Steef Engels, Tim Sparwasser, Wendy W. J. Unger, Yvette van Kooyk   +18 more
core   +4 more sources