Results 71 to 80 of about 70,942 (317)

Sialic Acids in Health and Disease

Biologics
Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers.
Gerardo N. Guerrero-Flores, Fayth M. Butler, Veronica L. Martinez Marignac, Guangyu Zhang, Fabio J. Pacheco, Danilo S. Boskovic   +5 more
doaj   +1 more source

Carbohydrates great and small, from dietary fiber to sialic acids: How glycans influence the gut microbiome and affect human health

Gut Microbes, 2021
Gut microbiome composition depends heavily upon diet and has strong ties to human health. Dietary carbohydrates shape the gut microbiome by providing a potent nutrient source for particular microbes.
Joanna K Coker, Oriane Moyne, Dmitry A. Rodionov, Karsten Zengler   +3 more
doaj   +1 more source

Evaluation of N-Acetylmannosamine Administration to Restore Sialylation in GNE-Deficient Human Embryonal Kidney Cells

Frontiers in Bioscience-Landmark, 2023
Background: A key mechanism in the neuromuscular disease GNE myopathy (GNEM) is believed to be that point mutations in the GNE gene impair sialic acid synthesis – maybe due to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) activity ...
Emilia Peters, Philipp Selke, Kaya Bork, Rüdiger Horstkorte, Astrid Gesper   +4 more
doaj   +1 more source

Glycosidation of sialic acid.

Journal of Synthetic Organic Chemistry, Japan, 1989
N-Acetylneuraminic acid (Neu5Ac), a typical sialic acid, located at the non-reducing ends of carbohydrate chains of glycoproteins and glycolipids plays an important role in biological phenomena. The synthesis of oligosaccharides which contain Neu5Ac has focused with clarification of their vital functions.
Kaoru Okamoto, Toshio Goto
openaire   +2 more sources

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Sialic acid accelerates the electrophoretic velocity of injured dorsal root ganglion neurons

Neural Regeneration Research, 2015
Peripheral nerve injury has been shown to result in ectopic spontaneous discharges on soma and injured sites of sensory neurons, thereby inducing neuropathic pain.
Chen-xu Li, Guo-ying Ma, Min-fang Guo, Ying Liu   +3 more
doaj   +1 more source

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site [PDF]

, 2018
Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic ...
Abramson, Jeff,, Andersson, Rebecka,, Beis, Konstantinos,, Bengtsson-Palme, Johan,, Bisignano, Paola,, Caing-Carlsson, Rhawnie,, Claesson, Elin,, Dobson, Renwick C.J.,, Dunevall, Elin,, Farewell, Anne,, Friemann, Rosmarie,, Goyal, Parveen,, Grabe, Michael,, Indiveri, Cesare,, Lund University., Nilsson, Ulf J.,, North, Rachel A.,, Paz, Aviv,, Pochini, Lorena,, Ramaswamy, S.,, Scalise, Mariafrancesca,, Wahlgren, Weixiao Y.,   +21 more
core   +3 more sources

Treatment with Plasma Activated (Salt) Water Sterilizes Macromolecular Coatings While Maintaining Their Integrity and Functionality

Advanced Materials Interfaces, EarlyView.
PDMS samples were covalently coated with mucin glycoproteins and then treated with either plasma activated water (PAW) or saline (PAS) as a means of disinfection. The samples could be successfully sterilized without compromising the structural integrity or functionality of those coatings.
Bernardo Miller Naranjo, Markus Ahrens, Ádám Nemes, Petra Mela, Oliver Lieleg   +4 more
wiley   +1 more source

Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging

BMC Biology
Background Anemonefish association with sea anemones is a prime example of mutualistic symbiosis. These fish live inside the sea anemone, benefitting from the protection of its toxic nematocysts, and in return, protect the anemone from its own predators.
Natacha Roux, Clément Delannoy, Shin-Yi Yu, Saori Miura, Lilian Carlu, Laurence Besseau, Takahiro Nakagawa, Chihiro Sato, Ken Kitajima, Yann Guerardel, Vincent Laudet   +10 more
doaj   +1 more source

Ácidos siálicos: da compreensão do seu envolvimento em processos biológicos ao desenvolvimento de fármacos contra o agente etiológico da gripe Sialic acids: from the comprehension of their involvement in biological processes to antiinfluenza drug design

Química Nova, 2005
Sialic acids are nine-carbon carbohydrates that occur widely in nature and occupy the terminal portions of some glycoproteins and glycolipids of cell membranes.
Ângelo de Fátima, Lúcia Helena Brito Baptistella, Ronaldo Aloise Pilli, Luzia Valentina Modolo   +3 more
doaj   +1 more source