Results 91 to 100 of about 20,212 (212)
Inhibition of sialidase activity as a therapeutic approach
, 2018 Victor Yu Glanz,1 Veronika A Myasoedova,2 Andrey V Grechko,3 Alexander N Orekhov2,4 1Department of Genetics, Cytology and Bioengineering, Faculty of Biology and Medicine, Voronezh State University, Voronezh, Russia; 2Laboratory of Angiopathology ...
Grechko AV +3 more
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Sialidase sensitivity of rotaviruses revisited
, 2009 Rotaviruses have been designated as 'sialidase sensitive' or 'sialidase insensitive', based on how their entry into cells is affected by treating cells with sialidases.
Kang, Gagandeep +5 more
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Free energy computations identify the mutations required to confer trans-sialidase activity into Trypanosoma rangeli sialidase [PDF]
, 2013 Trypanosoma rangeli's sialidase (TrSA) and Trypanosoma cruzi's trans-sialidase (TcTS) are members of the glycoside hydrolase family 33 (GH-33). They share 70% of sequence identity and their crystallographic Cα RMSD is 0.59 Å.
Roitberg, Adrián +2 more
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Detection of sialidase gene and sialidase activity in Gardnerella isolates.
, 2016 A) Quantitative fluorometry of adjusted sialidase activity (rate of increase in fluorescence adjusted for optical density of culture) confirms that all subgroup B isolates and 3/36 subgroup C isolates are sialidase positive, and all subgroup A and D ...
Teenus Paramel Jayaprakash (312062) +5 more
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Effects of trypsin treatment on NanI sialidase.
, 2013 Panel A, Sialidase enzymatic activity was measured for 0.005 U/ml of purified NanI sialidase or 0.005 U/ml of purified NanI sialidase that had been treated for 1 h with 15 µg/ml of trypsin (note: following this treatment, trypsin activity was blocked ...
Bruce A. McClane (45208) +4 more
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BiomoleculesThis narrative review summarizes current data on the role of desialylation of low-density lipoproteins (LDL) as a key initiating mechanism of atherogenesis that precedes oxidative modification. The structural and functional significance of sialic acid in
Tatyana I. Kovyanova +6 more
doaj +1 more source
Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2
, 2012 Sialidases or neuraminidases catalyze the hydrolysis of terminal sialic acid residues from sialyl oligosaccharides and glycoconjugates. Despite successes in developing potent inhibitors specifically against influenza virus neuraminidases, the progress in
Khedri, Zahra +6 more
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Sialidase of rat hepatomas: qualitative and quantitative comparison with rat liver sialidase.
Gan, 1984 The subcellular distribution of sialidase in rat hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene was studied by using sialyllactose as a substrate in the pH range of 4.0-7.0. As found in rat liver, the activity was recovered largely in the mitochondrial/lysosomal fraction with an optimal pH of 4.5 and in the cytosolic fraction with an optimal ...
MIYAGI, Taeko +2 more
openaire +2 more sources
The Human Lysosomal Sialidase Promoter [PDF]
, 2002 Tay-Sachs disease and its related disorders (GM2 gangliosidoses) are neurodegenerative diseases caused by the excessive accumulation of ganglioside GM2, an otherwise non-toxic plasma membrane component, in the lysosomes of cells of the central nervous ...
Johnson, Matthew
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, 2003 Trypanosomes express an enzyme called trans-sialidase (TS), which enables the parasites to transfer sialic acids from the environment onto trypanosomal surface molecules.
Lange, Hans +17 more
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