Results 131 to 140 of about 4,367 (168)

[Clinical value of carbohydrate antigens, sialyl Lewis-x and sialyl Lewis-a in gastrointestinal cancer].

Nihon Geka Gakkai zasshi, 1996
To evaluate clinical importance of the expression of sialyl Lewis-X (sLe(x)) and sialyl Lewis-a antigen (sLe(a)) in gastrointestinal cancers, we examined immunohistochemically expression of the two antigens in esophageal, gastric, colorectal, and pancreatic cancer.
S, Nakamori, I, Arai, S, Okamura, S, Imaoka, H, Furukawa, T, Kabuto, O, Ishikawa, Y, Sasaki, M, Kameyama, T, Iwanaga   +9 more
openaire   +1 more source

Sialyl Lewis^x: A “Pre‐Organized Water Oligomer”?

Angewandte Chemie International Edition, 2012
Organized and released: Sialyl Lewis(x) (sLe(x)) represents a "pre-organized water oligomer", that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of ...
Binder, Florian P. C., Lemme, Katrin, Preston, Roland C., Ernst, Beat   +3 more
openaire   +3 more sources

Expression of the carbohydrate antigens Sialyl Lewis a, Sialyl Lewis x and Lewis x in the placentae of patients with miscarriages

Geburtshilfe und Frauenheilkunde, 2020
Z Ma, L Peng, H Yang, C Kuhn, S Mahner, U Jeschke, V von Schönfeldt   +6 more
openaire   +1 more source

Increased expression of sialyl Lewis A and sialyl Lewis X in liver metastases of human colorectal carcinoma.

Invasion & metastasis, 1996
Sialyl Lewis A (SLA) and sialyl Lewis X (SLX) have been shown to be specific ligands for endothelial leukocyte adhesion molecule-1 (ELAM-1), and may be involved in the process of adhesion between cancer cells and endothelium. We used immunohistochemical methods to study the expression of SLA, SLX and CEA in both primary tumors and matched metastatic ...
N, Yamada, Y S, Chung, K, Maeda, T, Sawada, T, Ikehara, H, Nishino, M, Okuno, M, Sowa   +7 more
openaire   +1 more source

Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression—The Warburg effect revisited

Glycoconjugate Journal, 2003
Cell adhesion mediated by selectins and their carbohydrate ligands, sialyl Lewis X and sialyl Lewis A, figures heavily in cancer metastasis. Expression of these carbohydrate determinants is markedly enhanced in cancer cells, but the molecular mechanism that leads to cancer-associated expression of sialyl Lewis X/A has not been well understood.
openaire   +2 more sources

Expression of sialyl Lewis(x) in hepatocellular carcinoma.

Hepato-gastroenterology, 1996
Expression of the sialyl Lewis(x) antigen, a cell adhesion molecule, was studied immunohistochemically in patients with hepatocellular carcinomas.Fifty-six patients who underwent curative hepatic resections from July 1984 to October 1990 were studied.Hepatocellular staining patterns of the sialyl Lewis(x) in cancerous or noncancerous regions were ...
A, Tori, A, Harada, A, Nakao, T, Nonami, M, Ito, H, Takagi   +5 more
openaire   +1 more source

Total synthesis of sialyl Lewis X

Carbohydrate Research, 1991
A, Kameyama, H, Ishida, M, Kiso, A, Hasegawa   +3 more
openaire   +2 more sources

A convenient and efficient synthesis of sialyl Lewis X.

Bioscience, biotechnology, and biochemistry, 1998
A convenient synthesis of the sialyl Lewis X (sLe(x)) tetrasaccharide, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc (8), as a carbohydrate ligand for selectins is described. The key step is the reaction between NeuAc alpha 2-3GalSMe (5) as a glycosyl donor and the suitably protected Fuc alpha 1-3GlcNAc derivative (4) as the glycosyl acceptor by ...
K, Baba, N, Iwata, H, Hamajima, T, Ikami, H, Ishida, A, Hasegawa, M, Kiso   +6 more
openaire   +1 more source

Novel mimics of sialyl Lewis X

Bioorganic & Medicinal Chemistry, 2001
Anne Marinier, Alain Martel, Carol Bachand, Serge Plamondon, Brigitte Turmel, Jean-Paul Daris, Jacques Banville, Philippe Lapointe, Carl Ouellet, Pierre Dextraze, Marcel Menard, John J.K Wright, Julie Alford, Debbie Lee, Paul Stanley, Xina Nair, Gordon Todderud, Kenneth M Tramposch   +17 more
openaire   +1 more source

Synthèse stéréocontrôlée de glycosides : application à la synthèse de Lewis X, Sialyle Lewis X et mimiques de Sialyle Lewis X

1999
Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.
openaire   +1 more source