Results 121 to 130 of about 4,367 (168)

Transiently binding antibody fragments against Lewis x and sialyl-Lewis x

Journal of Immunological Methods, 2006
Biomolecular recognition is often characterised by low affinity where many weak interactions work either alone or in concert, resulting in an inherent dynamic situation. For example the well-studied weak binding of cell-cell interactions is predominantly based on a range of carbohydrates that interact with numerous (protein) ligands.
Reine, Johansson, Mats, Ohlin, Bo, Jansson, Sten, Ohlson   +3 more
openaire   +2 more sources

Synthesis of Thio‐Linked Analogues of Lewis X and Sialyl Lewis X

Liebigs Annalen, 1997
AbstractThe synthesis of thio‐linked Lewis X and sialyl Lewis X‐derived epitopes 3–5 has been achieved using a small number of building blocks. The key building‐block was 1‐O‐silyl‐protected 4‐S‐acetyl‐2,6‐di‐O‐benzoyl‐3‐S‐(2,3,4‐tri‐O‐acetyl‐α‐L‐fucopyranosyl)‐3,4‐dithio‐β‐D‐glucopyranose (15), which was obtained from the fucosyl donor 6 together with
Thomas Eisele, Richard R. Schmidt
openaire   +1 more source

Core saccharide dependence of sialyl Lewis X biosynthesis

Glycoconjugate Journal, 2008
The sialyl-Lewis X (SLe(x)) determinant is important in leukocyte extravasation, metastasis and bacterial adhesion. The role of the protein, N-glycan and O-glycan core structures for the biosynthesis of SLe(x) in vivo by fucosyltransferases (FucTs) is not known.
Jonas, Löfling, Jan, Holgersson
openaire   +2 more sources

A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis

Nature, 1993
To identify cell adhesion molecules required for angiogenesis, we used an in vitro model in which bovine capillary endothelial cells can be induced to form capillary-like tubes. Monoclonal antibodies directed against the carbohydrate epitopes sialyl Lewis-X and sialyl Lewis-A inhibited capillary formation.
M, Nguyen, N A, Strubel, J, Bischoff
openaire   +2 more sources

Sialyl Lewis X, Lewis X, and N-acetyllactosamine expression on normal and glaucomatous eyes

Current Eye Research, 1999
Sialyl Lewis X (sLex), Lewis X (Lex), and N-acetyllactosamine are carbohydrate chains of neolactoglycoconjugates which are expressed by specific cell types and are important in the functioning of cells within an organism. This study attempts to determine the expression of these glycoconjugates on the conjunctiva, cornea, and trabecular meshwork (TM) of
A J, Terraciano, N, Wang, J S, Schuman, G, Haffner, N, Panjwani, Z, Zhao, Z, Yang   +6 more
openaire   +2 more sources

Cytomegalovirus induces sialyl Lewis(x) and Lewis(x) on human endothelial cells.

Transplantation, 2000
Cytomegalovirus (CMV) is the primary viral cause of complications in transplant recipients. We sought to understand the mechanisms of its dissemination and induction of vascular disease, which may lead to transplant complications. Sialyl Lewis(x) (sLe(x)) and Lewis(x) (Le(x)) are known for their roles in mediating cell adhesion and as tumor-associated ...
C M, Cebulla, D M, Miller, D A, Knight, B R, Briggs, V, McGaughy, D D, Sedmak   +5 more
openaire   +2 more sources

Expression of Sialyl Lewis a, Sialyl Lewis x, Lewis y, Gal-3, Gal-7, STMN1 and p16 in cervical dysplasia

Future Oncology, 2016
Cervical intraepithelial neoplasia (CIN) is commonly divided into three grades. Guidelines increasingly recommend surgery only in CIN 3 lesions. We investigated markers to evaluate differences in CIN 2 and 3 lesions as well as possible predictors for regression/progression in CIN 2 lesions.Biopsies (n = 128) of healthy cervical tissue and CIN 1-3 were ...
Kolben, Theresa M., Kraft, Franziska, Kolben, Thomas, Goess, Christine, Semmlinger, Anna, Dannecker, Christian, Schmoeckel, Elisa, Mayr, Doris, Sommer, Nora N., Mahner, Sven, Jeschke, Udo   +10 more
openaire   +2 more sources

A novel mimic of the sialyl Lewis x determinant

Tetrahedron Letters, 1993
Abstract The syntheses of two novel disaccharides are described which block the interaction of the lectin domain of E-selectin with its glycosylated ligands on neutrophils.
Nigel M. Allanson, Alan H. Davidson, Fionna M. Martin   +2 more
openaire   +1 more source

Synthesis of a novel analogue of sialyl Lewis X

Tetrahedron Letters, 1995
Abstract Two different strategies have been developed in order to synthesise an analogue and potential mimic of sialyl Lewis X that incorporates a carboxymethyl group and a C 2 -symmetric 2,3-butanediol unit as replacements for the sialic acid and the N-acetylglucosamine residues respectively.
Jeremy C. Prodger, Mark J. Bamford, Paul M. Gore, Duncan S. Holmes, Victoria Saez, Peter Ward   +5 more
openaire   +1 more source

Chemoenzymatic synthesis of GM3, Lewis x and sialyl Lewis x oligosaccharides in 13C-enriched form

Tetrahedron Letters, 1997
Abstract In connection with studies on the solution and protein-bound conformation of oligosaccharides, we had reason to consider the application of 13C-enriched sugars. Herein we describe the synthesis of ganglioside GM3 trisaccharide (1), Lewis x trisaccharide (2) and the sialyl Lewis x tetrasaccharide (3) from [U13C]- D -Glc, [U13C]- L ...
Probert, Mark A., Milton, Mark J., Harris, Richard, Schenkman, Sergio, Brown, Jonathan M., Romans, Steven W., Field, Robert A.   +6 more
openaire   +3 more sources