Results 11 to 20 of about 17,841 (204)

A glyco-engineering approach for site-specific conjugation to Fab glycans

mAbs, 2023
Effective processes for synthesizing antibody-drug conjugates (ADCs) require: 1) site-specific incorporation of the payload to avoid interference with binding to the target epitope, 2) optimal drug/antibody ratio to achieve sufficient potency while ...
Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert   +10 more
doaj   +1 more source

Haploinsufficiency of the Attention-Deficit/Hyperactivity Disorder Risk Gene St3gal3 in Mice Causes Alterations in Cognition and Expression of Genes Involved in Myelination and Sialylation

Frontiers in Genetics, 2021
Genome wide association meta-analysis identified ST3GAL3, a gene encoding the beta-galactosidase-alpha-2,3-sialyltransferase-III, as a risk gene for attention-deficit/hyperactivity disorder (ADHD).
Olga Rivero, Olga Rivero, Judit Alhama-Riba, Hsing-Ping Ku, Matthias Fischer, Gabriela Ortega, Péter Álmos, David Diouf, Daniel van den Hove, Klaus-Peter Lesch, Klaus-Peter Lesch, Klaus-Peter Lesch   +11 more
doaj   +1 more source

Interaction of Polysialic Acid with CCL21 Regulates the Migratory Capacity of Human Dendritic Cells [PDF]

, 2009
Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs). Immature DCs (iDCs) are situated in the periphery where they capture pathogen. Subsequently, they migrate as mature DCs (mDCs) to draining lymph nodes to activate T cells.
A MartIn-Fontecha, AD Elbein, C Cebo, C Reis e Sousa, C Vizzardelli, C Zuber, E Ong, E Scandella, G Penna, GJ Randolph, J Banchereau, J Finne, J Hirose, J Huang, J Jenner, JB Lowe, Juan J. García-Vallejo, KM Veerman, M Bax, M Bros, M Eckhardt, M Frosch, MA Toscano, Manja Litjens, Marieke Bax, MC Dieu, Olivier Neyrolles, R Forster, R Morgan, RM Steinman, S Curreli, S Yanagihara, Sandra J. van Vliet, U Rutishauser, U Yabe, Yvette van Kooyk   +35 more
core   +21 more sources

Lipoprotein sialylation in atherosclerosis: Lessons from mice

Frontiers in Endocrinology, 2022
Sialylation is a dynamically regulated modification, which commonly occurs at the terminal of glycan chains in glycoproteins and glycolipids in eukaryotic cells.
Liming Yu, Jun Peng, Chieko Mineo, Chieko Mineo   +3 more
doaj   +1 more source

Comprehensive landscape of the ST3GAL family reveals the significance of ST3GAL6-AS1/ST3GAL6 axis on EGFR signaling in lung adenocarcinoma cell invasion

Frontiers in Cell and Developmental Biology, 2022
Sialylation aberration has been implicated in lung cancer development by altering signaling pathways. Hence, it is urgent to identify key sialyltransferases in the development of lung adenocarcinoma (LUAD), which is a common malignant subtype of non ...
Jiaxuan Li, Yiming Long, Yiming Long, Jingya Sun, Jiajun Wu, Xiao He, Xiao He, Simei Wang, Simei Wang, Xiongbiao Wang, Xiongbiao Wang, Xiayi Miao, Ruimin Huang, Ruimin Huang, Ruimin Huang, Jun Yan, Jun Yan   +16 more
doaj   +1 more source

Structural Insights in Mammalian Sialyltransferases and Fucosyltransferases: We Have Come a Long Way, but It Is Still a Long Way Down

Molecules, 2021
Mammalian cell surfaces are modified with complex arrays of glycans that play major roles in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid and fucose in particular have high levels in tumor cells, with positive ...
Ravneet Kaur Grewal, Abdul Rajjak Shaikh, Suresh Gorle, Manjeet Kaur, Paula Alexendra Videira, Luigi Cavallo, Mohit Chawla   +6 more
doaj   +1 more source

Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]

, 2018
The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć, Kamila Kozłowska, Marta Ząbczyńska   +2 more
core   +1 more source

Effect of membrane lipids on the lactosylceramide molecular species specificity of CMP-N-acetylneuraminate:lactosylceramide sialyltransferase

Journal of Lipid Research, 1993
It has previously been shown that when the molecular species specificity of rat liver Golgi CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase was determined, using as the substrate lactosylceramide (LacCer) incorporated into liposomes ...
H Kadowaki, MA Grant, LA Williams
doaj   +1 more source

Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]

, 2015
O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi, Kenyond, Nicholas J, Li, Yanhong, Louie, Angelique Y, Muthana, Musleh M, Santra, Abhishek, Tasnima, Nova, Yu, Hai, Zeng, Jie   +8 more
core   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source