Results 21 to 30 of about 11,605 (209)
eLife, 2023 Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. Sialylation relies on a dedicated pathway involving evolutionarily conserved enzymes, including CMP-sialic acid ...
Hilary Scott +13 more
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Frontiers in Microbiology, 2018 The capsular polysaccharide (CPS) represents a key virulence factor for most encapsulated streptococci. Streptococcus suis and Group B Streptococcus (GBS) are both well-encapsulated pathogens of clinical importance in veterinary and/or human medicine and
David Roy +9 more
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Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells
Frontiers in Immunology, 2018 Humoral immunity depends on intrinsic B cell developmental programs guided by systemic signals that convey physiologic needs. Aberrant cues or their improper interpretation can lead to immune insufficiency or a failure of tolerance and autoimmunity.
Eric E. Irons, Joseph T. Y. Lau
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Free and bound forms of sialic acid in blood plasma of patients with chronic lymphocytic leukemia
Regulatory Mechanisms in Biosystems, 2015 The level of free and bound forms of sialic acids (SА) was investigated in chronic lymphocytic leukemia (CLL) and at different stages of receiving chemotherapy.
O. V. Netronina
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Sialidase and Sialyltransferase Inhibitors: Targeting Pathogenicity and Disease
Frontiers in Molecular Biosciences, 2021 Sialidases (SAs) and sialyltransferases (STs), the enzymes responsible for removing and adding sialic acid to other glycans, play essential roles in viruses, bacteria, parasites, and humans.
William H. D. Bowles, Tracey M. Gloster
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Sialyltransferases functions in cancers
Frontiers in Bioscience, 2012 Abnormally elevated levels of sialylated tumor associated carbohydrate antigens are frequently described at the surface of cancer cells and/or secreted in biological fluids. It is now well established that this over-expression may result from deregulation in sialyltransferases enzymatic activity involved in their biosynthesis, but the precise molecular
Harduin-Lepers, Anne +5 more
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Multifaceted role of sialylation in prion diseases
Frontiers in Neuroscience, 2016 Mammalian prion or PrPSc is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of a sialoglycoprotein called the prion protein or PrPC. Sialylation of the prion protein N-linked glycans was discovered more than 30 years
Ilia V Baskakov +3 more
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Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells
Frontiers in Immunology, 2020 Humoral immunity is an effective but metabolically expensive defense mechanism. It is unclear whether systemic cues exist to communicate the dynamic need for antigen presentation and immunoglobulin production.
Eric E. Irons +2 more
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JIMD Reports, 2023 GM3 synthase deficiency (GM3SD) is caused by biallelic variants in ST3GAL5. The ganglioside GM3, enriched in neuronal tissues, is a component of lipid rafts and regulates numerous signaling pathways.
Natasha Rudy +7 more
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Advances in Cancer Biology - Metastasis, 2021 Aberrant glycosylation, particularly sialylation is considered a significant characteristic of malignancy. Aberrant sialylation has been connected with several neoplastic disorders. The role of abnormal sialylation in oral cancer blood, on the other hand,
Mallikarjun Goni +5 more
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