Results 21 to 30 of about 17,841 (204)
Frontiers in Microbiology, 2018 The capsular polysaccharide (CPS) represents a key virulence factor for most encapsulated streptococci. Streptococcus suis and Group B Streptococcus (GBS) are both well-encapsulated pathogens of clinical importance in veterinary and/or human medicine and
David Roy +9 more
doaj +1 more source
Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells
Frontiers in Immunology, 2020 Humoral immunity is an effective but metabolically expensive defense mechanism. It is unclear whether systemic cues exist to communicate the dynamic need for antigen presentation and immunoglobulin production.
Eric E. Irons +2 more
doaj +1 more source
Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]
, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi +2 more
core +2 more sources
Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells
Frontiers in Immunology, 2018 Humoral immunity depends on intrinsic B cell developmental programs guided by systemic signals that convey physiologic needs. Aberrant cues or their improper interpretation can lead to immune insufficiency or a failure of tolerance and autoimmunity.
Eric E. Irons, Joseph T. Y. Lau
doaj +1 more source
Sialylation of vasorin by ST3Gal1 facilitates TGF-β1-mediated tumor angiogenesis and progression. [PDF]
, 2019 ST3Gal1 is a key sialyltransferase which adds α2,3-linked sialic acid to substrates and generates core 1 O-glycan structure. Upregulation of ST3Gal1 has been associated with worse prognosis of breast cancer patients.
Chang, Margaret Dah-Tsyr +15 more
core +2 more sources
Marine Bacterial Sialyltransferases
Marine Drugs, 2010 Sialyltransferases transfer N-acetylneuraminic acid (Neu5Ac) from the common donor substrate of these enzymes, cytidine 5’-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac), to acceptor substrates.
Takeshi Yamamoto
doaj +1 more source
Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches [PDF]
, 2013 Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex ...
Daniotti, Jose Luis +4 more
core +2 more sources
eLife, 2023 Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. Sialylation relies on a dedicated pathway involving evolutionarily conserved enzymes, including CMP-sialic acid ...
Hilary Scott +13 more
doaj +1 more source
Distribution of glycan motifs at the surface of midgut cells in the cotton leafworm (Spodoptera littoralis) demonstrated by lectin binding [PDF]
, 2017 Glycans are involved in many biological phenomena, including signal transduction, cell adhesion, immune response or differentiation. Although a few papers have reported on the role of glycans in the development and proper functioning of the insect midgut,
Els J. M. Van Damme +5 more
core +2 more sources
Free and bound forms of sialic acid in blood plasma of patients with chronic lymphocytic leukemia
Regulatory Mechanisms in Biosystems, 2015 The level of free and bound forms of sialic acids (SА) was investigated in chronic lymphocytic leukemia (CLL) and at different stages of receiving chemotherapy.
O. V. Netronina
doaj +1 more source