Results 31 to 40 of about 10,746,438 (360)

The Vaso-Occlusive Pain Crisis in Sickle Cell Disease: Definition, Pathophysiology, and Management.

European Journal of Haematology, 2020
Early diagnosis, treatment, and prevention of a vaso-occlusive crisis (VOC) is critical to the management of patients with sickle cell disease. It is essential to differentiate between VOC-associated pain and chronic pain, hyperalgesia, neuropathy, and ...
D. Darbari, V. Sheehan, S. Ballas
semanticscholar   +1 more source

Protein Phosphatase-1 Regulates Expression of Neuregulin-1

Biology, 2016
Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova, Kareem Washington, Jamie Rotimi, Namita Kumari, Kahli A. Smith, Xiaomei Niu, Marina Jerebtsova, Sergei Nekhai   +7 more
doaj   +1 more source

Odisha Revisited: A Personal Account

Frontiers in Medicine, 2021
In 1986, a paper in the Lancet was the first to collate hematology, molecular findings, and clinical features of homozygous sickle cell (SS) disease in India.
Graham R. Serjeant, Andreas E. Kulozik, Beryl E. Serjeant   +2 more
doaj   +1 more source

Comparison of US Federal and Foundation Funding of Research for Sickle Cell Disease and Cystic Fibrosis and Factors Associated With Research Productivity

JAMA Network Open, 2020
This cross-sectional study compares disease-specific federal and foundation funding for sickle cell disease and cystic fibrosis research and assesses the factors associated with research productivity.
Faheem Farooq, P. Mogayzel, S. Lanzkron, C. Haywood, J. Strouse   +4 more
semanticscholar   +1 more source

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

Blood Advances, 2016
: The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment suggests a potential restriction of HIV-1 infection in SCD. We
Namita Kumari, Tatiana Ammosova, Sharmin Diaz, Xionghao Lin, Xiaomei Niu, Andrey Ivanov, Marina Jerebtsova, Subhash Dhawan, Patricia Oneal, Sergei Nekhai   +9 more
doaj   +1 more source

Using DNA testing for the precise, definite, and low-cost diagnosis of sickle cell disease and other Haemoglobinopathies: findings from Tanzania

BMC Genomics, 2021
Background Sickle cell disease (SCD) is an important cause of under-five mortality. Tanzania is the 5th country in the world with the highest births prevalence of SCD individuals. Significant advances in the neonatal diagnosis of SCD using rapid point-of-
Heavenlight Christopher, Adam Burns, Emmanuel Josephat, Julie Makani, Anna Schuh, Siana Nkya   +5 more
doaj   +1 more source

An Imaging Flow Cytometry Method to Measure Citrullination of H4 Histone as a Read-out for Neutrophil Extracellular Traps Formation

Bio-Protocol, 2021
The formation of neutrophil extracellular traps (NETs) is thought to play a critical role in infections and propagating sterile inflammation. Histone citrullination is an essential and early step in NETs formation, detectable prior to the formation of ...
Emilia Barbu, Venina Dominical, Laurel Mendelsohn, Swee Lay Thein   +3 more
doaj   +1 more source

When Actions Speak Louder Than Words - Racism and Sickle Cell Disease.

New England Journal of Medicine, 2020
Racism and Sickle Cell Disease As medical leaders around the United States issue statements denouncing racial injustice and calling for the dismantling of racism, we must ensure that these pledges ...
A. Power-Hays, Patrick T McGann
semanticscholar   +1 more source

Recent Advances in the Treatment of Sickle Cell Disease

Frontiers in Physiology, 2020
Sickle cell anemia (SCA) was first described in the Western literature more than 100 years ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies that have contributed to a better understanding of its pathophysiology ...
Gabriel Salinas Cisneros, S. Thein
semanticscholar   +1 more source

The additional genetic diagnosis of homozygous sickle cell disease in a patient with Waardenburg-Shah syndrome: a case report

Journal of Medical Case Reports, 2019
Background It is important that multiple genetic diagnoses are not missed. This case report describes the clinical features and management of a patient with co-inheritance of Waardenburg syndrome type 4 or Waardenburg-Shah syndrome, an extremely rare ...
Angela E. Rankine-Mullings, Graham Serjeant, Zachary Ramsay, Neil A. Hanchard, Monika Asnani   +4 more
doaj   +1 more source