Results 41 to 50 of about 10,746,438 (360)
Frontiers in Medicine, 2021 Patients with sickle cell disease often undergo frequent blood transfusions. This increases their exposure to red blood cell alloantigens of donor units, thus making it more likely that they produce alloantibodies.
Salomé Conrath +6 more
doaj +1 more source
The Red Blood Cell—Inflammation Vicious Circle in Sickle Cell Disease
Frontiers in Immunology, 2020 Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS), which polymerizes under deoxygenation, and induces the sickling of red blood ...
E. Nader, M. Romana, P. Connes
semanticscholar +1 more source
A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease.
New England Journal of Medicine, 2019 BACKGROUND Deoxygenated sickle hemoglobin (HbS) polymerization drives the pathophysiology of sickle cell disease. Therefore, direct inhibition of HbS polymerization has potential to favorably modify disease outcomes.
E. Vichinsky +21 more
semanticscholar +1 more source
RadioGraphics, 2001 Sickle cell anemia (SCA) is a disease caused by production of abnormal hemoglobin, which binds with other abnormal hemoglobin molecules within the red blood cell to cause rigid deformation of the cell. This deformation impairs the ability of the cell to pass through small vascular channels; sludging and congestion of vascular beds may result, followed ...
G J, Lonergan +2 more
openaire +2 more sources
Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin
Haematologica, 2013 Ferroportin Q248H mutation has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. Some investigators have reported that ferroportin Q248H is degraded after
Sergei Nekhai +9 more
doaj +1 more source
Pathophysiology of Sickle Cell Disease.
Annual Review of Pathology, 2019 Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made in the elucidation of the pathogenesis of its protean complications, which has inspired recent advances in targeted molecular therapies. In SCD, a single amino acid
P. Sundd, M. Gladwin, E. Novelli
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein +3 more
wiley +1 more source
Transition Readiness of Pediatric Sickle Cell Patients to Adult Clinic in a Teaching Hospital, Ghana
Advances in HematologyConclusion: The study revealed a high transition readiness among pediatric patients. In general, the patients had high confidence transitioning to an adult clinic and the ability to manage their own healthcare.
Aaron Kwasi Nartey +7 more
doaj +1 more source
Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania
EBioMedicine, 2017 Fetal hemoglobin (HbF) and peripheral hemoglobin oxygen saturation (SpO2) both predict clinical severity in sickle cell disease (SCD), while reticulocytosis is associated with vasculopathy, but there are few data on mechanisms.
Siana Nkya +10 more
doaj +1 more source
International Journal of Neonatal Screening, 2020 Hemoglobin separation techniques are the most commonly used laboratory methods in newborn screening and confirmatory testing programs for hemoglobinopathies.
Lisa M. Shook +2 more
doaj +1 more source