Results 71 to 80 of about 10,746,438 (360)

Antiviral response and HIV-1 inhibition in sickle cell disease

iScience
Summary: Sickle cell disease (SCD) is characterized by hemolysis, vaso-occlusion, and ischemia. HIV-1 infection was previously shown to be suppressed in SCD PBMCs.
Namita Kumari, Asrar Ahmad, Clemilson Berto-Junior, Andrey Ivanov, Fayuan Wen, Xionghao Lin, Sharmin Diaz, Iheanyi Okpala, James G. Taylor, VI, Marina Jerebtsova, Sergei Nekhai   +10 more
doaj   +1 more source

Cerebral hemodynamics and oxygenation in adult patients with sickle cell disease after stem cell transplantation [PDF]

, 2023
Liza Afzali‐Hashemi, Elisabeth Dovern, Koen Baas, Anouk Schrantee, John C. Wood, Aart J. Nederveen, Erfan Nur, Bart J. Biemond   +7 more
openalex   +1 more source

Sickle Cell Disease—Genetics, Pathophysiology, Clinical Presentation and Treatment

International Journal of Neonatal Screening, 2019
Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in the β-globin chain.
B. Inusa, L. Hsu, Neeraj Kohli, Anissa Patel, K. Ominu-Evbota, K. Anie, W. Atoyebi   +6 more
semanticscholar   +1 more source

Differential sensitivity of midline development to mitosis during and after primitive streak extension

Developmental Dynamics, EarlyView.
Abstract Background Midline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline morphogenesis in non‐amniotes can occur without mitosis, through Planar Cell Polarity (PCP) signaling. By contrast, amniotes utilize both cellular processes for developing the early midline landmark, the primitive streak (PS).
Zhiling Zhao, Rieko Asai, Takashi Mikawa
wiley   +1 more source

Búsqueda de hemoglobinas anormales en los recién nacidos en las grandes alturas.

Revista Médica Herediana, 1997
Se hizo un muestreo para detectar hemoglobinas anormales en Recién Nacidos (RN) de tres ciudades andinas situadas en el Perú: Cerro de Pasco, Huancayo y Puno. Estas ciudades estan situadas en altitudes que fluctúan entre los 3,500 a 4,400 m.
Dante ROA, María del Pilar AGUINAGA, Wilson RUIZ, Víctor ULLOA, Ernest TURNER   +4 more
doaj  

Sickle Cell Safari [PDF]

Blood, 1973
Abstract A narrative concerning mass screening of a large population at risk for sickle hemolobin, glucose-6-phosphate dehydrogenase deficiency, anemia, and lead poisoning is presented. At the time of writing, more than one-tenth of a black community totaling over 104,000 individuals have been tested.
openaire   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Nutritional Potential, Phytochemical Content, In Vivo Antioxidant, and Antanemic Potential of Musa paradisiaca Flower

Food Chemistry International, EarlyView.
After collecting Musa paradisiaca leaves, some were dried and others were used to produce aqueous extracts. The extracts and powders were characterized and then administered to rats made anaemic by PHZ. After 14 days of administration of the two samples, the rats were euthanized and it was observed that after 9 days of treatment, the aqueous extract ...
Josée Rebeca Nombo, Jethro Roland Misse Ngangue Ekwala, Somon Régine Tuem, Stéphano Tene Tambo, Merlin Ngafon Nchoutpouen, Valery Jean François Nsoga, Jules Christophe Koule Manz, Jordan Mekui Nwotue, Mathieu Ndomou   +8 more
wiley   +1 more source

Relationships Between Markers of Iron Status and Hematological Parameters in Patients With Sickle Cell Disease

Advances in Hematology
Based on the relationship between the intracellular concentration of sickle hemoglobin S (HbS) and the delay that occurs prior to the onset of sickling following deoxygenation, targeting the intracellular HbS concentration is a recognized therapeutic ...
Nermi L. Parrow, Jason M. Doherty, Anna Conrey, Swee Lay Thein, Robert E. Fleming   +4 more
doaj   +1 more source

Newborn Sickle Cell and Thalassaemia Screening Programme: Automating and Enhancing the System to Evaluate the Screening Programme

International Journal of Neonatal Screening, 2019
Good information is needed to demonstrate that a screening programme is meeting its objectives, to measure performance against standards and to ensure that action is taken if standards are not met.
Catherine Coppinger, Robyn O’Loughlin
doaj   +1 more source