Modelling of Sickle Cell Anemia Patients Response to Hydroxyurea using Artificial Neural Networks [PDF]
arXiv, 2019 Hydroxyurea (HU) has been shown to be effective in alleviating the symptoms of Sickle Cell Anemia disease. While Hydroxyurea reduces the complications associated with Sickle Cell Anemia in some patients, others do not benefit from this drug and experience deleterious effects since it is also a chemotherapeutic agent.
arxiv
Red Blood Cell Sphericity Index Obtained by Defocusing Microscopy and Retinopathy Severity in Sickle Cell Disease [PDF]
arXiv, 2021 Proliferative sickle cell retinopathy (PSCR) is the most important ocular manifestation of sickle cell disease (SCD), but understanding of its pathophysiology remains incomplete. Red blood cell (RBC) deformability has been identified as a critical factor in SCD and is intrinsically related with cell sphericity index (SI).
arxiv
Duodenal perforation: an unusual complication of sickle cell anemia
The Pan African Medical Journal, 2014 Duodenal perforation in childhood is a rare condition with a high mortality rate if not treated surgically. Primary gastroduodenal perforation is frequently associated with peptic ulcer and exhibits a positive family history.
Can Acıpayam +5 more
doaj +1 more source
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. [PDF]
PLoS ONE, 2012 Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia.
Jacqueline N Milton +19 more
doaj +1 more source
Measuring Pain in Sickle Cell Disease using Clinical Text [PDF]
arXiv, 2020 Sickle Cell Disease (SCD) is a hereditary disorder of red blood cells in humans. Complications such as pain, stroke, and organ failure occur in SCD as malformed, sickled red blood cells passing through small blood vessels get trapped. Particularly, acute pain is known to be the primary symptom of SCD.
arxiv
Thermodynamically Consistent Diffuse Interface Model for Cell Adhesion and Aggregation [PDF]
arXiv, 2022 A thermodynamically consistent phase-field model is introduced for simulating multicellular deformation, and aggregation under flow conditions. In particular, a Lennard-Jones type potential is proposed under the phase-field framework for cell-cell, cell-wall interactions.
arxiv
Nutritional status of young children with inherited blood disorders in western Kenya. [PDF]
, 2014 To determine the association between a range of inherited blood disorders and indicators of poor nutrition, we analyzed data from a population-based, cross-sectional survey of 882 children 6–35 months of age in western Kenya.
Ruth, LJ +4 more
core +1 more source
A Novel Deep Learning based Model for Erythrocytes Classification and Quantification in Sickle Cell Disease [PDF]
arXiv, 2023 The shape of erythrocytes or red blood cells is altered in several pathological conditions. Therefore, identifying and quantifying different erythrocyte shapes can help diagnose various diseases and assist in designing a treatment strategy. Machine Learning (ML) can be efficiently used to identify and quantify distorted erythrocyte morphologies.
arxiv
Blood, 2015 Early transcranial Doppler (TCD) screening of the Créteil sickle cell anemia (SCA)-newborn cohort, and rapid initiation of transfusion programs, resulted in successful prevention of overt strokes, but a high cumulative risk of silent cerebral infarcts ...
F. Bernaudin +11 more
semanticscholar +1 more source
Sickle cell disease complicating pregnancy: A retrospective study
Journal of Dr. NTR University of Health Sciences, 2017 Introduction: Sickle cell disease is an uncommon cause of anemia and jaundice during pregnancy. Sickle cell crisis may lead to several maternal and fetal complications. Aims: To study maternal and fetal complications in pregnant patients with sickle cell
B Kavitha, Basanta H Hota
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