Results 91 to 100 of about 1,827,024 (396)

Macrophage HIV-1 Gene Expression and Delay Resolution of Inflammation in HIV-Tg Mice

Viruses, 2020
While antiretroviral therapy increases the longevity of people living with HIV (PLWH), about 30% of this population suffers from three or more concurrent comorbidities, whose mechanisms are not well understood.
Marina Jerebtsova, Asrar Ahmad, Namita Kumari, Ornela Rutagarama, Sergei Nekhai   +4 more
doaj   +1 more source

Knowledge of family health program practitioners in Brazil about sickle cell disease: a descriptive, cross-sectional study [PDF]

, 2011
BACKGROUND: Although sickle cell disease is an important public health problem in Brazil, there is a gap in the literature on the level of knowledge of primary health care professionals about the treatment and management of sickle cell disease. Therefore,
Antônio P Caldeira, Ludmila MX Gomes, Magda M Vieira, Tatiana C Reis, Thiago LA Barbosa   +4 more
core   +2 more sources

Sexuality and sickle cell disease [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2013
For decades, sickle cell disease (SCD) was mainly considered a childhood disease, since until 1973 life expectancy was 14 years(1). However, most children with SCD outlive this barrier(2). Newborn screening, prophylactic penicillin, and effective vaccinations against Haemophilus influenzae type b and Streptococcus pneumonia are some of the factors ...
openaire   +6 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

Blood Advances, 2016
: The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment suggests a potential restriction of HIV-1 infection in SCD. We
Namita Kumari, Tatiana Ammosova, Sharmin Diaz, Xionghao Lin, Xiaomei Niu, Andrey Ivanov, Marina Jerebtsova, Subhash Dhawan, Patricia Oneal, Sergei Nekhai   +9 more
doaj  

Pharmacokinetic Characterization of Iopamidol and Iohexol for Optimizing Measured Glomerular Filtration Rate Assessment in Clinical Practice and Drug Development

The Journal of Clinical Pharmacology, EarlyView.
Abstract Accurate kidney function assessment supports healthcare and clinical decision‐making in practice and drug development. Measured glomerular filtration rate (mGFR) via iohexol clearance is the gold standard, but cost, supply issues, and logistical challenges limit its clinical use.
Levi Hooper, Michael Heung, Lu Wang, Aleksas Matvekas, Radin Alikhani, Michael T. Kenes, Kathleen A. Stringer, Bruce A. Mueller, Manjunath P. Pai   +8 more
wiley   +1 more source

The Physical Foundation of Vasoocclusion in Sickle Cell Disease [PDF]

, 2012
The pathology of sickle cell disease arises from the occlusion of small blood vessels because of polymerization of the sickle hemoglobin within the red cells. We present measurements using a microfluidic method we have developed to determine the pressure
Aprelev, Alexey, Ferrone, Frank A., Meier, Maureen, Noh, Hongseok (Moses), Stephenson, William   +4 more
core   +1 more source

Reducing Health Care Disparities in Sickle Cell Disease: A Review

Public health reports (1974), 2019
Sickle cell disease (SCD) is an inherited blood disorder most common among African American and Hispanic American persons. The disease can cause substantial, long-term, and costly health problems, including infections, stroke, and kidney failure, many of
LaTasha H Lee, K. Smith-Whitley, Sonja Banks, G. Puckrein   +3 more
semanticscholar   +1 more source

Outcomes of POCUS‐Guided Peripheral Intravenous Access in Difficult Venous Access Patients: A Systematic Review and Meta‐Analysis

Journal of Clinical Ultrasound, EarlyView.
POCUS‐guided peripheral intravenous (PIV) access significantly improves success rates in patients with difficult venous access. This technique leads to higher first‐attempt success, fewer attempts, shorter procedure times, and reduced complications compared to standard methods, making it a safer and more efficient option for challenging cases ...
Hany A. Zaki, Hussam Elmelliti, Benny Ponappan, Ahmed Shaban, Amira Shaban, Mohammed F. Abosamak, Eman E. Shaban   +6 more
wiley   +1 more source

Studies on the Hemoglobin of Cooley's Anemia and Cooley's Trait [PDF]

, 1952
The diseases sickle cell anemia and Cooley's anemia (also known as thalassemia or Mediterranean anemia) have associated with them "minor" or "trait" forms of the disease in which the symptomatology is minimal, and the abnormalities in the red cells are ...
Rich, Alexander
core