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Sickle Cell Disease—Genetics, Pathophysiology, Clinical Presentation and Treatment
Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in the β-globin chain.
B. Inusa+6 more
semanticscholar +1 more source
Point‐Counterpoint: Adult patients in children's hospitals
Abstract Adults continue to be admitted to children's hospitals for a variety of reasons. But should they? Transfer from the pediatric to adult hospital setting is the standard of high‐quality care for any young adult. Adult hospitalists are equipped to care for these patients.
Meg Groom+3 more
wiley +1 more source
Insights Into Elevated Distortion Product Otoacoustic Emissions In Sickle Cell Disease: Comparisons of Hydroxyurea-treated and Non-treated Young Children [PDF]
Distortion product otoacoustic emissions (DPOAEs) were examined in 15 normal- hearing African-American children between the ages of 6 and 14 years with homozygous sickle cell disease (SCD), who were on a regimen of hydroxyurea (HDU), a drug that reduces ...
Adams+75 more
core +1 more source
Navigating Identity and Resilience: Supporting Black Women With Multiple Sclerosis
ABSTRACT Black women with multiple sclerosis developed and maintained cultural expectations of strength, self‐reliance, and caregiving known as superwoman schema (SWS) while also navigating their disability identity. The SWS framework guided this study and highlighted unique factors that contributed to the help‐seeking behaviors of Black women.
Jessica S. Henry+3 more
wiley +1 more source
Coexisting Sickle Cell Anemia and Sarcoidosis: A Management Conundrum! [PDF]
Sickle cell disease and Sarcoidosis are conditions that are more common in the African American population. In this report we share an unfortunate patient who had hepatic sarcoidosis but could not receive steroids since that precipitated acute liver ...
Gollahalli, Nagesh S., Nutan, FNU
core +3 more sources
Luspatercept in Transfusion‐Dependent β‐Thalassemia: The Benefit Is Real, and So Are the Risks
American Journal of Hematology, EarlyView.
Khaled M. Musallam
wiley +1 more source
ABSTRACT Black Americans with disabilities experience a range of inequities including barriers to access, social stigmatization, and health outcomes that are greater than both their White and their nondisabled peers. This conceptual article explains in detail these inequities. The authors provide an overview of the existing models of disability used in
Aaron Albright+2 more
wiley +1 more source
Extramedullary hematopoiesis (EMH) serves as a compensatory mechanism in chronic hemolytic anemias, such as thalassemia, and can result in spinal cord compression.
Konstantinos Manganas+4 more
doaj +1 more source
AAPT Diagnostic Criteria for Chronic Sickle Cell Disease Pain [PDF]
Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high health care costs. Although episodic acute pain is the hallmark of this disorder, there is an increasing awareness that chronic pain is part of the pain ...
Aguilar+89 more
core +3 more sources