Results 111 to 120 of about 1,827,024 (396)

SICKLE CELL DISEASE AND PREGNANCY

Mediterranean Journal of Hematology and Infectious Diseases, 2019
Abstract   Sickle Cell Disease (SCD) is a group of inherited single-gene autosomal recessive disorders caused by the ‘sickle’ gene, which affects haemoglobin structure. Sickle cell anemia is the most common hemoglobinopathy worldwide. The burden of sickle cell disease in pregnancy has been exponentially increasing with more number of women ...
Dipty Jain, Pooja Lodha, Roshan Colah, Prachi Atmapoojya, Prachi Atmapoojya   +4 more
openaire   +5 more sources

MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez, Thomas Lilieholm, Walter F. Block   +2 more
wiley   +1 more source

Sickle-cell disease [PDF]

Nature, 2014
Lauren Gravitz, Stephen Pincock
openaire   +5 more sources

Early detection and management of extracranial arteriopathy reduces the incidence of silent cerebral infarcts in sickle cell anemia: a long-term prospective cohort study

Haematologica
Previous reports about the Creteil newborn-cohort (1988/Apr-2007) showed that the risk of silent cerebral infarcts (SCI) remained high (37.1%) by age 14 in children with sickle cell anemia (SCA) and intracranial time-averaged mean maximum velocity ...
Francoise Bernaudin, Cecile Arnaud, Annie Kamdem, Jenny Youn, Manuela Vasile, Isabelle Hau, Fouad Madhi, Aline Malterre, Celine Delestrain, Ralph Epaud, Camille Jung, Suzanne Verlhac   +11 more
doaj   +1 more source

Examining the secret life of the spleen in sickle cell disease. [PDF]

Hemasphere
HemaSphere, Volume 9, Issue 6, June 2025.
Ladu A, Hibbs SP.
europepmc   +2 more sources

Solenostemon monostachyus, Ipomoea involucrata and Carica papaya seed oil versus Glutathione, or Vernonia amygdalina: Methanolic extracts of novel plants for the management of sickle cell anemia disease [PDF]

, 2012
Background Sickle cell disease (SCD) is a genetic disease caused by an individual inheriting an allele for sickle cell hemoglobin from both parents and is associated with unusually large numbers of immature blood cells, containing many long, thin ...
Adekeye, B. Temitope, Adeyemi , A.O., Afolabi , Israel Sunmola, Bisi-Adeniyi, Tolulope Dorcas, Fajimi, O.D, Ogunleye, D.O, Osikoya, I.O, Usoro, P.I   +7 more
core   +1 more source

Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease

Nucleic Acids Research, 2019
Sickle cell disease (SCD) is a monogenic disorder that affects millions worldwide. Allogeneic hematopoietic stem cell transplantation is the only available cure.
S. H. Park, Ciaran M. Lee, D. Dever, Timothy H. Davis, J. Camarena, W. Srifa, Yankai Zhang, Alireza Paikari, Alicia K Chang, M. Porteus, V. Sheehan, Gang Bao   +11 more
semanticscholar   +1 more source

Thrombosis and Sickle Cell Disease

Seminars in Thrombosis and Hemostasis, 2011
Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has the unique property of polymerizing when deoxygenated. The pathophysiology of acute and chronic clinical manifestations of SCD have shown the central role of dense, dehydrated red cells in acute and chronic clinical manifestations of this pathology.
DE FRANCESCHI, Lucia, Cappellini MD, OLIVIERI, Oliviero   +2 more
openaire   +3 more sources

Pre‐operative transcranial Doppler ultrasound assessment of cerebral collateral circulation in children undergoing veno‐arterial extracorporeal membrane oxygenation or cardiac surgery

Journal of Medical Radiation Sciences, EarlyView.
A pre‐cannulation survey of the circle of Willis (CoW) using transcranial Doppler (TCD) ultrasound was implemented to assess cerebral collateral circulation in children undergoing VA ECMO or cardiac surgery with cervical cannulation. The technique, in use since 2019, employs high‐end ultrasound platforms to assess brain morphology, haemorrhage and ...
Tristan Reddan, Michael Malouf, Prem Venugopal, Jennifer Powell   +3 more
wiley   +1 more source

Delayed hemolytic transfusion reaction in children with sickle cell disease: first 5-year retrospective study in mainland France

Haematologica, 2022
Claire Falguière, Slimane Allali, Bassem Khazem, Annie Kamdem, Cécile Arnaud, Marie Belloy, Corinne Guitton, Marie-Hélène Odièvre, Sophie Pertuisel, Cecile Dumesnil, Cécile Guillaumat, Nathalie Garrec, Alexandra Gauthier, Perrine Mahe, Valerie Soussan-Banini, Laure Le-Carrer, Etienne Merlin, Audrey David, Beatrice Pellegrino, Catherine Paillard, Jean-Francois Brasme, Marie Lagarde, France Pirenne, Corinne Pondarre   +23 more
doaj   +1 more source