Results 111 to 120 of about 94,881 (302)

Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation

The FEBS Journal, EarlyView.
This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley   +1 more source

In Silico Assessment of Limited Blood Sampling Strategies for Individualised Pharmacokinetic‐guided Dosing of Efanesoctocog Alfa in Haemophilia A Patients

Haemophilia, EarlyView.
ABSTRACT Introduction Efanesoctocog alfa is a novel factor VIII (FVIII) concentrate with a unique molecular design that enables Von Willebrand Factor‐independent clearance in patients with haemophilia A. Limited sampling strategies (LSSs) are necessary to implement accurate pharmacokinetic (PK)‐guided dosing for efanesoctocog alfa in clinical practice.
Jelien den Hollander, Marjon H. Cnossen, Ron A. A. Mathôt   +2 more
wiley   +1 more source

Hemodynamic profile of cerebral arteries using transcranial Doppler in children with sickle cell disease compared to children without sickle cell disease: Prospective analytical study

BMC Pediatrics
Background Cerebral vasculopathy is a frequent and serious complication of major sickle cell disease syndromes. Transcerebral Doppler (TCD) can detect stenosis of the main arteries at the base of the skull before stroke occurs, and initiate therapy to ...
Patrick Landu Kinkunda, Aliocha Natuhoyila Nkodila, Joël Kashale Mutamba, Orlin Mamona Yindula, Roger Izeidi Gangale, Lilly Mokulayanga, Émeraude Manzombi, Djo Mbo-M. Iyoto, Lys Makwanza, Cynthia Bukumba Minouche, Stéphane Tongo Yanda, Antoine Aundu Molua, Jean Tshibola Mukaya   +12 more
doaj   +1 more source

Determining Predictors of Academic Performance in Children and Adolescents with Sickle Cell Disease and Comparing It with Siblings in Benin

Adolescents
Background: One of the major challenges for children and adolescents with sickle cell disease (SCD) is academic performance. Objectives: Our study aimed to evaluate the academic performance of children and adolescents with SCD in Benin and compare it to ...
Bonaventure G. Ikediashi, Selma Gomez, Edwige Dedjinou, Alban Zohoun, Roukiyath Adjile Edjide Amoussa, Bernice Quenum, Gisela Michel, Eva De Clercq, Katharina Roser   +8 more
doaj   +1 more source

Impact of Isovolemic Hemodilution-Red Cell Exchange on Health-Related Quality of Life in Patients With Sickle Cell Disease: A Pilot Study. [PDF]

J Clin Apher
ABSTRACT Sickle cell disease (SCD) negatively affects health‐related quality of life (HRQoL). Isovolemic hemodilution (IHD) red‐cell exchange (RCE) is being increasingly used to treat SCD‐related complications, but its impact on HRQoL has not been characterized.
Murray A, Sidhu D, Rydz N, Goodyear D, Uminski K.   +4 more
europepmc   +2 more sources

Pregnancy outcomes in sickle cell disease: a retrospective cohort study from two tertiary centres in the UK

, 2010
A R Chase, Mamta Sohal, John Howard, R. Laher, Andrew McCarthy, D. Mark Layton, Eugene Oteng‐Ntim   +6 more
openalex   +1 more source

Outcome and Challenges of Kidney Transplant in Patients with Sickle Cell Disease [PDF]

, 2013
U. H. Okafor, E Aneke
openalex   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Starting to Understand the Natural History of Sickle Cell Disease in African Countries

, 2022
David C. Rees
openalex   +1 more source

Position statement from the British Society of Blood and Marrow Transplantation and Cellular Therapy on insertional oncogenesis in gene‐engineered advanced cell therapy products for treatment of haematological disorders

British Journal of Haematology, EarlyView.
S. Ghorashian, R. Sanderson, J. Lee, A. Black, M. A. O'Reilly, D. I. Marks, J. Snowden, D. Richardson, E. Olavarria   +8 more
wiley   +1 more source