Results 141 to 150 of about 1,827,024 (396)

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

open access: yesFrontiers in Microbiology, 2019
Ebola virus (EBOV) is a non-segmented negative-sense RNA virus that causes a severe human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of the Congo has resulted to date in over 2500 confirmed cases including over 1500 ...
Xionghao Lin   +16 more
doaj   +1 more source

Safety and efficacy of blood exchange transfusion for priapism complicating sickle cell disease. [PDF]

open access: yes, 2016
BACKGROUND: Priapism is unwanted painful penile erection that affects about 36% of boys and men with sickle cell disease (SCD) most of whom have sickle cell anemia. Clinically, priapism could be stuttering, minor, or major.
Adeyoju   +23 more
core   +2 more sources

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology.

open access: yesBlood, 2016
Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic anemia, episodic vaso-occlusion, and progressive organ damage. Current management of the disease remains symptomatic or preventative.
Dachuan Zhang   +3 more
semanticscholar   +1 more source

Pregnancy‐ and Disease‐Related Morbidity Among Medicaid Enrollees With Sickle Cell Disease

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Whereas pregnancy in sickle cell disease (SCD) is considered high risk, there is limited understanding of pregnancy‐ and SCD‐related morbidity to inform clinical practice and health policy. Procedure This retrospective cohort study aimed to describe pregnancy‐ and disease‐related morbidity among individuals with SCD for up to 1 year
Mariam Kayle   +10 more
wiley   +1 more source

J Rare Dis Res Treat [PDF]

open access: yes
Sickle cell disease affects more than 100,000 individuals in the United States, among whom disease severity varies considerably. One factor that influences disease severity is the sickle cell disease genotype.

core  

The nephropathy of sickle cell trait and sickle cell disease

open access: yesNature Reviews Nephrology, 2022
K. Ataga, S. Saraf, V. Derebail
semanticscholar   +1 more source

Sickle cell disease: Reducing the global disease burden

open access: yesInternational Journal of Laboratory Hematology, 2019
Sickle cell disease has been largely an invisible global health issue, especially in regions of high incidence mainly due to lack of awareness among both the local health policy makers and the public.
Joy Mburu, I. Odame
semanticscholar   +1 more source

Sickle Cell Disease and Stroke

open access: yesPediatric Neurology, 2019
Cerebral infarction is a common complication of sickle cell disease and may manifest as overt stroke or cognitive impairment associated with "silent" cerebral infarction on magnetic resonance imaging. Vasculopathy may be diagnosed on transcranial Doppler or magnetic resonance angiography. The risk factors in sickle cell disease for cognitive impairment,
Deborah Hirtz, Fenella J. Kirkham
openaire   +5 more sources

Optimizing Transcranial Doppler Screening for Stroke Prevention in Young African Children with Sickle Cell Disease

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background The greatest burden of sickle cell disease (SCD) globally occurs in sub‐Saharan Africa, where significant morbidity occurs secondary to SCD‐induced vasculopathy and stroke. Transcranial doppler (TCD) ultrasound grades the severity of vasculopathy, with disease modifying therapy resulting in stroke risk reduction in high‐risk ...
Derby Tembo   +18 more
wiley   +1 more source

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