Results 61 to 70 of about 1,827,024 (396)
Science Advances, 2020 Editing the fetal γ-globin promoters in hematopoietic stem cells from sickle cell disease patients induces therapeutic γ-globin levels. Sickle cell disease (SCD) is caused by a single amino acid change in the adult hemoglobin (Hb) β chain that causes Hb ...
Leslie Weber +18 more
semanticscholar +1 more source
Sickle cell disease with left ventricular non-compaction: A rare association [PDF]
, 2011 SummaryCardiac abnormalities described in sickle cell disease are pulmonary hypertension, dilated left or right atrium/ventricle, valvular abnormalities, hyperdynamic left ventricle with hypertrophy, and left or right ventriclular dysfunction.
Al-Mukhaini, Mohammed +1 more
core +1 more source
Advanced Science, EarlyView.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
Uncovering How Occupational Therapy Could Benefit Individuals Living with Sickle Cell Disease in Ghana [PDF]
, 2018 In 2017, with funding from a Summer Undergraduate Research Fellowship (SURF), I spent ten weeks in Kumasi, Ghana conducting research on how occupational therapy may be beneficial for individuals living with sickle cell disease.
D\u27Olympio, Carolyn
core +1 more source
Sickle cell anaemia and the experiences of young people living with the condition [PDF]
, 2018 This qualitative literature review examines the experiences of young people with Sickle Cell Anaemia (SCA). Sickle cell anaemia (SCA) is a condition acknowledged for its unpredictability, painful episodes and life threatening nature.
Ellis, M.R.C., Foster, N.
core +1 more source
Advanced Science, EarlyView.A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang +4 more
wiley +1 more source
Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology
EBioMedicine, 2015 Sickle cell anaemia (SCA) results from a single mutation in the β globin gene. It is seldom symptomatic in the first semester of life. We analysed the expression pattern of 9 adhesion molecules on red blood cells, in a cohort of 54 SCA and 17 non-SCA ...
Valentine Brousse +11 more
doaj +1 more source
Viruses, 2020 Human immunodeficiency virus (HIV)-infected individuals treated with anti-retroviral therapy often develop chronic non-infectious lung disease. To determine the mechanism of HIV-1-associated lung disease we evaluated the dynamics of lung leukocytes in ...
Marina Jerebtsova +4 more
doaj +1 more source
Sickle cell disease status among school adolescents and their tribal community in South Gujarat [PDF]
, 2009 Objectives: to create awareness, to screen samples of school adolescents and then to reach their community through them by doing surveillance for sickle cell disease. Design: Field based cross-sectional study. Settings: St Xavier`s high school and Vanraj
Chudasama, Rajesh K +3 more
core +1 more source
Primary stroke in a woman with sickle cell anemia responsive to hydroxyurea therapy. [PDF]
, 2014 The most common cause of stroke in children with sickle cell anemia is infarction due to ischemia. In adults, however, stroke is most commonly hemorrhagic in nature. Other causes of stroke in patients with sickle cell disease are very rare. In this short
Ballas, Samir K. +2 more
core +2 more sources