Results 81 to 90 of about 1,827,024 (396)

L-glutamine for sickle cell disease: Knight or pawn?

Experimental biology and medicine, 2020
Oxidative stress is an important contributor to the pathophysiology of sickle cell disease. The pathways involved are complex and interlinked. L-glutamine is an amino acid with myriad roles in the body, including the synthesis of antioxidants, such as ...
Alina Sadaf, C. Quinn
semanticscholar   +1 more source

The Role of the Brain's Pragmatic Language Network in Reading Comprehension in Autistic Children

Autism Research, EarlyView.
ABSTRACT One of the earliest and commonly reported symptoms of autism spectrum disorder (ASD) is a delay in language development. Such delay may sometimes accompany deficits which can have a long‐term impact on reading comprehension. It is frequently reported that autistic children exhibit significant difficulties in pragmatics, which is the ...
Elizabeth Valles‐Capetillo, McKayla R. Kurtz, Rajesh K. Kana   +2 more
wiley   +1 more source

Views of patients about sickle cell disease management in primary care: a questionnaire-based pilot study. [PDF]

, 2012
OBJECTIVES: To determine how patients with sickle cell disease (SCD) perceive the quality of care that they receive from their primary healthcare providers.
Aljuburi, G, Banarsee, R, Green, S, Knight, Y, Majeed, A, Ndive, C, Nkohkwo, A, Ojeer, P, Okoye, O, Oni, L, Phekoo, K   +10 more
core   +1 more source

Pulmonary hypertension in adolescents with sickle cell disease [PDF]

, 2016
Sickle cell disease consists of a group of disorders that have a similar mutation in at least one of the beta-globin chains of hemoglobin. This results in a change of the hemoglobin to sickle shaped cells when in the deoxygenated state.
Akinyemi, Katherine
core   +1 more source

Defining the phenotypes of sickle cell disease. [PDF]

, 2011
The sickle cell gene is pleiotropic in nature. Although it is a single gene mutation, it has multiple phenotypic expressions that constitute the complications of sickle cell disease.
Albers GW, Ballas SK, Ballas SK, Ballas SK, Ballas SK, Ballas SK, Banerjee S, Bellomo R, Bookchin RM, Brazier DJ, Dana MR, DeBaun MR, DeBaun MR, Dobson SR, Goldberg MF, Halabi-Tawil M, Hatton CS, Johnson CS, Karam LB, Koshy M, Ohene-Frempong K, Pearson HA, Powars D, Powell RW, Robertson KD, Rogers ZR, Samir K. Ballas, Shao SH, Vichinsky EP, Vichinsky EP, Vichinsky EP, West MS, Williams GC, Zimmerman SA   +33 more
core   +2 more sources

Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease

JAMA Network Open, 2019
Key Points Question What is the association between sickle cell disease and life expectancy and lifetime income? Findings This cohort simulation modeling study showed that projected life expectancy (54 vs 76 years) and quality-adjusted life expectancy ...
D. Lubeck, I. Agodoa, N. Bhakta, M. Danese, Kartik S. Pappu, Robin S. Howard, M. Gleeson, M. Halperin, S. Lanzkron   +8 more
semanticscholar   +1 more source

Calibrating Sickle Cell Disease [PDF]

Biophysical Journal, 2016
Sickle cell disease is fundamentally a kinetic disorder, in which cells containing the mutated hemoglobin (hemoglobin S; HbS) will cause occlusion if they sickle in the microvasculature, but have minimal (or no) consequences if they sickle in the venous return.
Donna Yosmanovich, Maria Rotter, Alexey Aprelev, Frank A. Ferrone   +3 more
openaire   +4 more sources

Techno‐Economic Analysis of Membrane‐Based Purification Platforms for AAV Vector Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Technologies for large‐scale manufacturing of viral vectors for gene therapies, such as tangential flow filtration and membrane chromatography, are under development. In these early stages of process development, techno‐economic analyses are useful for identifying membrane properties yielding the greatest impact on process performance. In this
Juan J. Romero, Eleanor W. Jenkins, Jacob I. Monroe, S. Ranil Wickramasinghe, Xianghong Qian, Dibakar Bhattacharyya, Scott M. Husson   +6 more
wiley   +1 more source

Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment

Haematologica
Cerebral arteriopathy (CA) in children with sickle cell disease (SCD) is classically described as chronic stenosis of arteries in the anterior brain circulation, leading to ischemic stroke. Some studies have however reported strokes in children with SCD
Sarah Liane Linguet, Suzanne Verlhac, Florence Missud, Laurent Holvoet-Vermaut, Valentine Brousse, Ghislaine Ithier, Alexandra Ntorkou, Emmanuelle Lesprit, Malika Benkerrou, Manoëlle Kossorotoff, Berengere Koehl   +10 more
doaj   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source