Results 81 to 90 of about 1,352,611 (298)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
AIP Advances, 2019 The effects of alkyl side-chain length on the interactions between imidazolium ionic liquids (ILs) and β-cyclodextrin (β-CD) were studied at ambient pressure and up to 2.5GPa.
Teng-Hui Wang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Driven translocation of a polymer: role of pore friction and crowding
, 2014 Force-driven translocation of a macromolecule through a nanopore is investigated by taking into account the monomer-pore friction as well as the "crowding" of monomers on the {\it trans} - side of the membrane which counterbalance the driving force ...
Dubbeldam, Johan L. A. +2 more
core +1 more source
Crystalline structure and thermotropic behavior of alkyltrimethylphosphonium amphiphiles [PDF]
, 2017 Quaternary organophosphonium salts bearing long alkyl chains are cationic surfactants of interest owing to their physical and biological properties.
Gamarra Montes, Ana +3 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Evaluation of esterification routes for long chain cellulose esters
Heliyon, 2019 Long chain cellulose esters are internally plasticized bio-based materials, which have good future potential in several applications such as coatings, films and plastics.
Pia Willberg-Keyriläinen +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
International Journal of Electrochemical Science, 2018 Modern automotive industry still relies on the lead-acid batteries as a power supply for starting, lighting and ignition applications. In order to provide efficient devices, manufacturers should control the quality and electrochemical properties of the ...
Kacper Kopczyński +6 more
doaj +1 more source
Dielectric catastrophe at the Mott transition
, 2000 We study the Mott transition as a function of interaction strength in the half-filled Hubbard chain with next-nearest-neighbor hopping t' by calculating the response to an external electric field using the Density Matrix Renormalization Group.
A. A. Ovchinnikov +23 more
core +1 more source