Results 81 to 90 of about 17,918 (286)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Forisome locations and positions inside sieve elements.
, 2015 A. Basal (downstream), central and apical (upstream) locations. B. Position1, Forisome tips in contact with the plasma membrane lining the sieve plate and the parietal plasma membrane, position 2 one tip in contact with the plasma membrane lining the ...
Alexandra C. U. Furch (832276) +2 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Sieve Element Structure and Function
, 2012 Thesis (Ph.D.), Botany, Washington State UniversityThe distribution of photosynthetically derived assimilates through plants occurs in specialized cells called sieve elements that are connected to each other forming a microfluidic system within the plant.
Mullendore, Daniel Leroy +1 more
core
Imaging of PP2-A1:GFP in sieve elements undergoing differentiation.
, 2015 Fluorescent PP2-A1:GFP protein observed in leaves of pSEOR2:PP2-A1:GFP plants. Images were obtained by CLSM. GFP fluorescence is shown in false color green, propidium iodide in nuclei is shown in red and plastid autofluorescence in magenta except in (e).
Frédéric Revers (158609) +7 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Influence of elliptical sieve movements on the functioning of the combine cleaning unit
Landtechnik, 2017 To increase the throughput of the cleaning unit in a combine harvester, an improvement of the separation process and thus an optimization of the mechanic and aerodynamic excitations is necessary. One opportunity to improve the functioning of the cleaning
Konstantin Beckmann +2 more
doaj +1 more source
Sieve-Element Characters of Ticodendron
Annals of the Missouri Botanical Garden, 1991 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +2 more sources
Sugar Coating the Phloem Sieve Element Wall [PDF]
Plant Physiology, 2018 Whereas fluorescent tagging of proteins has dramatically advanced the study of protein function in cell biology, similar approaches with walls have been difficult due to the few methods available to visualize polysaccharides and monitor their dynamic modifications.
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source