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2001
Sialic acids (Sia) are derivatives of the nine-carbon neuraminic acid monosaccharide (Fig. 1). To date, about 40 of these neuraminic acid modifications have been found to occur in nature (Table 1). Their structure, occurrence and metabolic pathways have been reviewed in detail (Rosenberg 1995; Kelm and Schauer 1997; Schauer and Kamerling 1997; Varki ...
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Sialic acids (Sia) are derivatives of the nine-carbon neuraminic acid monosaccharide (Fig. 1). To date, about 40 of these neuraminic acid modifications have been found to occur in nature (Table 1). Their structure, occurrence and metabolic pathways have been reviewed in detail (Rosenberg 1995; Kelm and Schauer 1997; Schauer and Kamerling 1997; Varki ...
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Siglecs that Associate with DAP12
2020Siglecs are a family of transmembrane receptor-like glycan-recognition proteins expressed primarily on leukocytes. Majority of Siglecs have an intracellular sequence motif called immunoreceptor tyrosine-based inhibitory motif (ITIM) and associate with Src homology region 2 domain-containing tyrosine phosphatase-1 (SHP-1), and negatively regulate ...
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Siglecs and their roles in the immune system
Nature Reviews Immunology, 2007Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-binding immunoglobulin-like lectins that are thought to promote cell-cell interactions and regulate the functions of cells in the innate and adaptive immune systems
Crocker, Paul R. +2 more
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Current Opinion in Pharmacology, 2005
Siglecs are sialic acid-binding Ig-like lectins expressed in a highly specific manner, and which are implicated in signaling and adhesive functions. The CD33-related siglecs represent a distinct subgroup that is undergoing rapid evolution within the innate immune system, with the potential to trigger apoptosis and provide inhibitory signals.
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Siglecs are sialic acid-binding Ig-like lectins expressed in a highly specific manner, and which are implicated in signaling and adhesive functions. The CD33-related siglecs represent a distinct subgroup that is undergoing rapid evolution within the innate immune system, with the potential to trigger apoptosis and provide inhibitory signals.
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CD33 (Siglec 3) and CD33-Related Siglecs
2012Sialic-acid-binding immunoglobulin-like lectins (Siglecs) bind sialic acids in different linkages in a wide variety of glycoconjugates. These membrane receptors are expressed in a highly specific manner, predominantly within haematopoietic system. Activating and inhibitory receptors act in concert to regulate cellular activation.
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Siglecs: From Biomodulation to Immunotherapy
Current Protein & Peptide ScienceBackground: Sialic acid-binding immunoglobulin-like lectins (Siglecs) are cell-surface immunological receptors predominantly expressed on immune cells such as monocytes, macrophages, and dendritic cells. They play a crucial role in regulating inflammatory processes in various diseases and serve as immunological ...
Jia, Chen +6 more
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Binding and Inhibition Assays for Siglecs
2006Protein-carbohydrate interactions are believed to be important in many biological processes involving cellular communication. Although many of the experimental approaches for studying protein-carbohydrate interactions are similar to those commonly employed in protein-protein interactions, several important aspects have to be taken into account in ...
Nadine, Bock, Sørge, Kelm
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CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder
Cell Metabolism, 2022Guoyun Chen +2 more
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