Results 171 to 180 of about 821,630 (331)

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

, 2016
José Manuel Entrena, Cristina Sánchez–Fernández, Francisco R. Nieto, Rafael González‐Cano, Sandra Yeste, Enrique J. Cobos, José M. Baeyens   +6 more
openalex   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study

Neuropsychiatric Disease and Treatment, 2013
Hideyuki Shimizu,1 Minoru Takebayashi,2 Masayuki Tani,1 Hiroaki Tanaka,1 Bun Yamagata,1 Kenzo Kurosawa,1 Hiroki Yamada,1 Mitsugu Hachisu,3 Kazue Hisaoka-Nakashima,2 Mami Okada-Tsuchioka,2 Masaru Mimura,4 Akira Iwanami11Department of Neuropsychiatry ...
Shimizu H, Takebayashi M, Tani M, Tanaka H, Yamagata B, Kurosawa K, Yamada H, Hachisu M, Hisaoka-Nakashima K, Okada-Tsuchioka M, Mimura M, Iwanami A   +11 more
doaj  

Sigma-1 Receptor Remodels Endoplasmic Reticulum Membrane [PDF]

Biophysical Journal, 2020
Vladimir Zhemkov, Ilya Bezprozvanny
openaire   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

A Test–Retest Paradigm of the Forced Swimming Test in Female Mice Is Not Valid for Predicting Antidepressant-Like Activity: Participation of Acetylcholine and Sigma-1 Receptors

, 2013
Jing Su, Noriko Hato-Yamada, Hiroaki Araki, Hiroyuki Yoshimura   +3 more
openalex   +2 more sources

Progress in the synthesis of a Technetium-labeled complex as a potential Sigma receptor binding ligand [PDF]

, 2005
only availableThe sigma receptors have been known to affect several physiological functions such as psychosis, depression and uncontrolled cell proliferation.
Austin, Jared, Lever, Susan Z., 1952-, Xu, Rong, 1977-   +2 more
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Sigma 1 receptor modulators as a new weapon against multiple sclerosis [PDF]

BioDiscovery, 2017
Simona Collina, Marta Rui, Giacomo Rossino, Serena Della Volpe, Daniela Rossi, Arianna Scuteri, Alessio Malacrida, Guido Cavaletti   +7 more
doaj   +3 more sources

Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. [PDF]

Sci Rep, 2020
Brimson JM, Akula KK, Abbas H, Ferry DR, Kulkarni SK, Russell ST, Tisdale MJ, Tencomnao T, Safrany ST.   +8 more
europepmc   +1 more source