Results 71 to 80 of about 821,630 (331)
The Evaluation of AZ66, A Highly Selective Sigma-1 and Sigma-2 Receptor Antagonist, For Its Anti-Convulsive Effects in C57BL/6 Mice [PDF]
, 2017 The Evaluation of AZ66, A Highly Selective Sigma-1 and Sigma-2 Antagonist, for Anticonvulsive Effects in C57Bl/6 Mice (Under the direction of Lisa Wilson and Dr. Christopher McCurdy) Sigma receptors have become a popular subject for research the past
Stone, Jamie
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
PLoS ONE, 2012 In addition to both the α1 adrenergic receptor and N-methyl-D-aspartate (NMDA) receptor antagonists, ifenprodil binds to the sigma receptor subtypes 1 and 2.
Tamaki Ishima, Kenji Hashimoto
doaj +1 more source
Evaluation of Sigma Ligand AZ66 Analgesic Potentiation of Cannabinoids [PDF]
, 2017 Sigma receptors have become a popular subject for research the past few decades, but there is still much mystery behind these receptors and how they work.
Morris, Jacqueline
core +1 more source
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
core +1 more source
A Review of the Human Sigma-1 Receptor Structure [PDF]
, 2017 The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential.
Ossa, F, Schnell, J, Ortega-Roldan, J
openaire +3 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
NeurotherapeuticsMemory impairment is among the most disabling features of depression and schizophrenia, yet remains largely untreated by available pharmacotherapies.
Kinga Sałaciak +16 more
doaj +1 more source
An Evaluation of the Relationship between Sigma-1 and Sigma-2 Receptors and the Endocannabinoid System [PDF]
, 2016 Within the past two decades, sigma receptors have become a popular area for research. Although much has been learned about their structure, subtypes, and functions; there is still much to be learned.
Miller, Jenn
core +10 more sources
In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells [PDF]
, 2019 Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens
A Ashkenazi +32 more
core +2 more sources