Results 81 to 90 of about 1,674,719 (294)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of Boron Addition on the Precipitation Behavior of S31254

Metals, 2018
To reduce the precipitation of σ phases and to improve the hot workability of S31254 steels, boron has been added into the composition of S31254 to a concentration of 40 ppm. The precipitation behavior was investigated before and after the addition
Jingang Bai, Yishi Cui, Jian Wang, Nan Dong, Muhammad Saqlain Qurashi, Hairui Wei, Yongchao Yang, Peide Han   +7 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Effect of the Temperature in the Mechanical Properties of Austenite, Ferrite and Sigma Phases of Duplex Stainless Steels Using Hardness, Microhardness and Nanoindentation Techniques

Metals, 2017
The aim of this work is to study the hardness of the ferrite, austenite and sigma phases of a UNS S32760 superduplex stainless steel submitted to different thermal treatments, thus leading to different percentages of the mentioned phases.
Gorka Argandoña, José F. Palacio, Carlos Berlanga, María V. Biezma, Pedro J. Rivero, Julio Peña, Rafael Rodriguez   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Investigating the sigma formation in homogenization treatment of the 309L stainless cast billet

Journal of Materials Research and Technology
309L is a low-carbon (0.03 wt% max) and high-alloy austenitic stainless steel, which is particularly valued for the welding filler wire application. The 309L cast billet is commonly used to produce ultra-fine welding filler wire.
Hung-Yang Chu, Min-Chang Wu, Ren-Kae Shiue, Sheng-Yuan Cheng   +3 more
doaj   +1 more source

Low-Temperature Mechanical Behavior of Super Duplex Stainless Steel with Sigma Precipitation

Metals, 2015
Experimental studies in various aspects have to be conducted to maintain stable applications of super duplex stainless steels (SDSS) because the occurrence rate of sigma phase, variable temperature and growth direction of sigma phase can influence ...
Seul-Kee Kim, Ki-Yeob Kang, Myung-Soo Kim, Jae-Myung Lee   +3 more
doaj   +1 more source

Phase Ordering Kinetics of One-Dimensional Non-Conserved Scalar Systems

, 1994
We consider the phase-ordering kinetics of one-dimensional scalar systems. For attractive long-range ($r^{-(1+\sigma)}$) interactions with $\sigma>0$, ``Energy-Scaling'' arguments predict a growth-law of the average domain size $L \sim t^{1/(1+\sigma ...
A. D. Rutenberg, A. J. Bray, A. J. Bray, A. J. Bray, A. J. Bray, A. J. Bray, A. J. Bray, A. J. Bray, B. Derrida, B. P. Lee, F. de Pasquale, F. J. Dyson, F. J. Dyson, G. Porod, H. Furukawa, H. Hayakawa, H. Hayakawa, H. Ikeda, H. Ikeda, J. G. Amar, J. K. Bhattacharjee, J. M. Kosterlitz, K. Kawasaki, K. Kawasaki, K. Kawasaki, N. Metoki, P. C. Hohenberg, P. Debye, S. M. Allen, T. J. Newman, T. Nagai, T. Nagai, T. Ohta, Y. Oono   +33 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source