Results 81 to 90 of about 5,116,497 (296)

Supporting universal access to affordable, quality health care [PDF]

, 2009
Honor Society of Nursing, Sigma Theta Tau International support for efforts to ensure access to equitable, affordable, quality health care services across the ...
Sigma Theta Tau International
core   +1 more source

Effect of Boron Addition on the Precipitation Behavior of S31254

Metals, 2018
To reduce the precipitation of σ phases and to improve the hot workability of S31254 steels, boron has been added into the composition of S31254 to a concentration of 40 ppm. The precipitation behavior was investigated before and after the addition
Jingang Bai, Yishi Cui, Jian Wang, Nan Dong, Muhammad Saqlain Qurashi, Hairui Wei, Yongchao Yang, Peide Han   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Effect of the Temperature in the Mechanical Properties of Austenite, Ferrite and Sigma Phases of Duplex Stainless Steels Using Hardness, Microhardness and Nanoindentation Techniques

Metals, 2017
The aim of this work is to study the hardness of the ferrite, austenite and sigma phases of a UNS S32760 superduplex stainless steel submitted to different thermal treatments, thus leading to different percentages of the mentioned phases.
Gorka Argandoña, José F. Palacio, Carlos Berlanga, María V. Biezma, Pedro J. Rivero, Julio Peña, Rafael Rodriguez   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Sigma Phase Stabilization by Nb Doping in a New High-Entropy Alloy in the FeCrMnNiCu System: A Study of Phase Prediction and Nanomechanical Response

Metals
The development of high-entropy alloys has been hampered by the challenge of effectively and verifiably predicting phases using predictive methods for functional design.
Angelo Oñate, Juan Pablo Sanhueza, Gleydis Dueña, Diego Wackerling, Sergio Sauceda, Christopher Salvo, Marian Valenzuela, Carlos Medina, Abdul Herrim Seidou, Jérôme Tchoufang Tchuindjang, Manuel Meléndrez, David Rojas, Anne Mertens, Víctor Tuninetti   +13 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Clinical scholarship resource paper [PDF]

, 1999
The task force conceived this publication as a means of communicating its deliberations to the wider membership of Sigma Theta Tau and the profession. It is intended less as a definitive statement on clinical scholarship and more as a work-in-progress ...
Sigma Theta Tau International
core   +1 more source

Influence of Isothermal Annealing in the 600 to 750 °C Range on the Degradation of SAF 2205 Duplex Stainless Steel

Corrosion and Materials Degradation
We studied the effect of isothermal annealing (600–750 °C, 1 to 1000 min) on the microstructure and mechanical properties of SAF 2205 duplex stainless steel.
Jaka Burja, Borut Žužek, Barbara Šetina Batič   +2 more
doaj   +1 more source