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SSCG With Hershey-Kiss Modulation Profile Using Dual Sigma-Delta Modulators
IEICE Electronics Express, 2010 This letter describes a spread spectrum clock generator (SSCG) circuit with the Hershey-Kiss modulation profile using two stacked sigma-delta modulators. The proposed Hershey-Kiss profile modulator generates various slopes to achieve non-linear modulation profile.
Jin-Ku Kang, Hyun-Bae Jin
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Medicinal Chemistry, 2021
Background: Sigma receptors (Rs), initially classified as an additional class of opioid receptors, are now recognized as a unique entity with no homology to opioid receptors divided into two distinct subtypes, namely σ1R and σ2R. σ1R-targeting ligands have been conceived and explored for the treatment of various neurodegenerative disorders and ...
Righetti G. +3 more
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Background: Sigma receptors (Rs), initially classified as an additional class of opioid receptors, are now recognized as a unique entity with no homology to opioid receptors divided into two distinct subtypes, namely σ1R and σ2R. σ1R-targeting ligands have been conceived and explored for the treatment of various neurodegenerative disorders and ...
Righetti G. +3 more
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Neuropharmacological Profile of a Novel and Selective Ligand of the Sigma Site: SR 31742A
Neuropharmacology, 1993The biochemical, electrophysiological and behavioural effects of SR 31742A, a novel and selective ligand of sigma sites in brain, labelled with (+)-[3H]3PPP (Ki = 5.3 +/- 0.3 nM), were investigated in rodents and compared with those of DA antagonists having (haloperidol) or not (spiroperidol) a high affinity for sigma sites. Like haloperidol but unlike
Martine Poncelet, G le Fur, R Steinberg
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Novel Sigma Receptor Ligands: Synthesis and Biological Profile
Journal of Medicinal Chemistry, 2007The aim of the present study was to investigate the biological profile of new substituted 1-phenyl-2-cyclopropylmethylamines. High affinity for both sigma subtypes was achieved when 4-phenylpiperidin-4-ol (4a-e) and 4-benzylpiperidine moieties were present (5a-e).
PREZZAVENTO, Orazio +11 more
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Effects of Conformational Distributions on Sigma Profiles in COSMO Theories
The Journal of Physical Chemistry A, 2005The charge density or sigma profile of a solute molecule is an essential component in COSMO (conductor-like screen model) based solvation theories, and its generation depends on the molecular conformation used. The usual procedure is to determine the conformation of an isolated molecule, and assume that this is unchanged when the molecule is placed in ...
Shu, Wang +3 more
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Neuropharmacological Profile of a Selective Sigma Ligand, Igmesine: A Potential Antidepressant
Neuropharmacology, 2001Igmesine is a selective sigma (sigma(1)) ligand that was reported to exert antidepressant action through an unknown mechanism of action. A number of neurochemical measures were taken in this study in efforts to understand its mode of action. Following 21-day drug treatments, the actions of igmesine on a number of neurochemical measures were ...
H C Akunne, T A Pugsley, F Roman
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Six Sigma for improving aesthetic defects in aluminum profiles facility
Facilities, 2017Purpose This paper aims to develop a quality plan to detect aesthetic defects in extruded aluminum profiles before the fabrication stage based on the Six Sigma improvement methodology in an aluminum facility. These defects are hard to be detected at the fabrication stage. It is also hard to be fixed in the site.
Laith A. Hadidi +2 more
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COSMO-SAC Sigma Profile Generation with Conceptual Segment Concept
Industrial & Engineering Chemistry Research, 2014Solvation thermodynamics-based models for predicting liquid-phase nonidealities and fluid-phase equilibria are gaining attention in modern chemical process and product development. Among this class of thermodynamic models, COSMO-RS and COSMO-SAC are two variants used extensively in industry. A key input to these models is the so-called sigma profile, i.
Md Rashedul Islam, Chau-Chyun Chen
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Boosting Graph Neural Networks with Molecular Mechanics: A Case Study of Sigma Profile Prediction
Journal of Chemical Theory and Computation, 2023Sigma profiles are quantum-chemistry-derived molecular descriptors that encode the polarity of molecules. They have shown great performance when used as a feature in machine learning applications. To accelerate the development of these models and the construction of large sigma profile databases, this work proposes a graph convolutional network (GCN ...
Dinis O. Abranches +2 more
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E-5842: A New Potent and Preferential Sigma Ligand. Preclinical Pharmacological Profile [PDF]
CNS Neuroscience & Therapeutics, 1998 X Guitart
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