Results 21 to 30 of about 61,509 (283)

Signal-Transducing Adaptor Protein-2 Modulates Fas-Mediated T Cell Apoptosis by Interacting with Caspase-8 [PDF]

The Journal of Immunology, 2012
Abstract We found that an adaptor protein, signal-transducing adaptor protein (STAP)-2, is a new member of the Fas–death-inducing signaling complex and participates in activation-induced cell death in T cells. STAP-2 enhanced Fas-mediated apoptosis and caspase-8 aggregation and activation in Jurkat T cells.
Yuichi Sekine, Chikako Yamamoto, Michinori Kakisaka, Ryuta Muromoto, Shigeyuki Kon, Dai Ashitomi, Natsuko Fujita, Akihiko Yoshimura, Kenji Oritani, Tadashi Matsuda   +9 more
semanticscholar   +4 more sources

Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice

Biological and Pharmaceutical Bulletin, 2008
Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7.
Osamu Ikeda, Yuichi Sekine, Ryuta Muromoto, Norihiko Ohbayashi, Akihiko Yoshimura, Tadashi Matsuda   +5 more
semanticscholar   +6 more sources

ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation [PDF]

Journal of Biological Chemistry, 2014
Background: The ESCRT-0 complex proteins, Hrs and STAM, cooperatively recognize ubiquitylated endosomal cargo. Results: Hrs is targeted to endosomes independently of STAM binding and dissociates from endosomes in a STAM binding-dependent manner ...
Katsuhiko Kojima, Yuji Amano, Kazuhisa Yoshino, Nobuyuki Tanaka, Kazuo Sugamura, Toshikazu Takeshita   +5 more
openalex   +2 more sources

Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance

Cells, 2022
Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-associated inflammation contributes to tumor initiation and progression.
Shigeru Hashimoto, Ari Hashimoto, Ryuta Muromoto, Yuichi Kitai, Kenji Oritani, Tadashi Matsuda   +5 more
doaj   +1 more source

Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling

Cells, 2021
The T cell antigen receptor (TCR) is expressed on T cells, which orchestrate adaptive immune responses. It is composed of the ligand-binding clonotypic TCRαβ heterodimer and the non-covalently bound invariant signal-transducing CD3 complex. Among the CD3
Frederike A. Hartl, Jatuporn Ngoenkam, Esmeralda Beck-Garcia, Liz Cerqueira, Piyamaporn Wipa, Pussadee Paensuwan, Prapat Suriyaphol, Pankaj Mishra, Burkhart Schraven, Stefan Günther, Sutatip Pongcharoen, Wolfgang W. A. Schamel, Susana Minguet   +12 more
doaj   +1 more source

Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition

Virulence, 2023
Streptococcus suis type 2 (SS2), a major emerging/re-emerging zoonotic pathogen found in humans and pigs, can cause severe clinical infections, and pose public health issues.
Xiaowu Jiang, Guijun Yu, Lexin Zhu, Abubakar Siddique, Dongbo Zhan, Linhua Zhou, Min Yue   +6 more
doaj   +1 more source

Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness. [PDF]

, 2020
Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and the proper engagement of its intracellular signal effector proteins.
Becker, S., Bhatt, A., Engelke, M., Erdmann, P., Griesinger, C., Hou, Z., Maier, J., Pirkuliyeva, S., Plitzko, J., Wienands, J., Wong, L.   +10 more
core   +2 more sources

Constitutive internalization and association with adaptor protein‐2 of the interleukin‐6 signal transducer gp130 [PDF]

FEBS Letters, 1998
The transmembrane protein gp130 is the common signalling receptor subunit for the interleukin‐6 (IL‐6)‐type cytokines. It has recently been shown that the cytoplasmic domain of gp130 contains a dileucine internalization motif and that endocytosis of gp130 occurs signal‐independent.
Thiel, Stefan, Dahmen, Heike, Martens, Astrid, Müller-Newen, Gerhard, Schaper, Fred, Heinrich, Peter, Graeve, Lutz   +6 more
openaire   +3 more sources

In-cell biochemistry using NMR spectroscopy. [PDF]

PLoS ONE, 2008
Biochemistry and structural biology are undergoing a dramatic revolution. Until now, mostly in vitro techniques have been used to study subtle and complex biological processes under conditions usually remote from those existing in the cell.
David S Burz, Alexander Shekhtman
doaj   +1 more source

STAM Prolongs Clear Cell Renal Cell Carcinoma Patients' Survival via Inhibiting Cell Growth and Invasion

Frontiers in Oncology, 2021
Background: Signal transducing adaptor molecule 1 (STAM1) was considered to mediate cell growth and be involved in multiple signaling pathways; however, no research on the role of STAM1 in any tumors has been published yet. Our study aimed to investigate
Tuo Deng, Zihao He, Xiaolu Duan, Di Gu, Chao Cai, Wenqi Wu, Yongda Liu, Guohua Zeng   +7 more
doaj   +1 more source