Results 81 to 90 of about 61,509 (283)
インターロイキン2 ジョウホウ デンタツ キコウ [PDF]
, 2003 Extensive studies on the IL-2 and IL-2 receptor system have established fundamental principles of immune responses and signal transducing mechanisms of hematopoietic cell proliferation and survival.
Asao Hironobu
core +1 more source
Positive and negative regulation of T cell responses by Lck-dependent signaling pathways [PDF]
, 2008 Appropriate T cell signaling is essential for the function of the human immune system. T cells regulate and direct the body’s response to foreign pathogens such as virus and bacteria, or threats from within in the form of cancerous cells. Aberrant T cell
Methi, Trond
core +1 more source
Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule
Journal of Biological Chemistry, 1997 We previously reported a new type of signal-transducing adaptor molecule, STAM, which was shown to be involved in cytokine-mediated intracellular signal transduction.
H. Asao +9 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Characterizing the Physiological Interfaces of the Histidine Kinase CheA: A TAM-IDS study [PDF]
, 2013 The core components of the bacterial chemosensory array, the transmembrane receptor, the histidine kinase CheA, and the adaptor protein CheW, organize into an extended hexagonal array typically located at one or both of the poles of bacterial cells ...
Ulliman, Caleb
core +2 more sources
Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells [PDF]
, 2014 Background In a classic model, Giα proteins including Gi1α, Gi2α and Gi3α are important for transducing signals from Giα protein-coupled receptors (GiαPCRs) to their downstream cascades in response to hormones and neurotransmitters.
Birnbaumer, Lutz +9 more
core +3 more sources
Journal of Biological Chemistry, 2003 Although some exceptional motifs have been identified, it is well known that the PXXP motif is the motif of ligand proteins generally recognized by the Src homology 3 (SH3) domain. SH3-ligand interactions are usually weak, with ordinary KD ∼ 10 μm.
T. Kaneko +6 more
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Analysis of the neuromuscular deficits caused by STAM1 deficiency
Current Research in NeurobiologyThe endosomal sorting complexes required for transport (ESCRT) pathway is composed of a series of protein complexes that are essential for sorting cargo through the endosome.
John W. McLean +7 more
doaj +1 more source
Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella [PDF]
, 2008 TNF receptor associated factor 1 (TRAF1) plays an important role in regulating the TNF signaling and protecting cells from apoptosis. In the present study, a TRAF1 gene has been cloned from grass carp (Ctenopharyngodon idella) by reverse transcription ...
Chang, M. X. +4 more
core +1 more source