Results 121 to 130 of about 517,159 (303)

Benefit of Hearing-Aid Amplification and Signal Enhancement for Speech Reception in Complex Listening Situations

Trends in Hearing
A major goal of hearing-device provision is to improve communication in daily life. However, there is still a large gap between the user's daily-life aided listening experience and hearing-aid benefit as assessed with established speech reception ...
Theresa Jansen, Laura Hartog, Dirk Oetting, Volker Hohmann, Hendrik Kayser   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

All-optical signal processing in highly nonlinear fibres

We review our recent work demonstrating two all-optical signal processing devices using high SBS threshold alumino-silicate highly nonlinear ...
Weerasuriya, R., Sygletos, S., Ellis, A.D., Parmigiani, F., Slavík, R., Jakobsen, D., Herstrøm, S., Petropoulos, P., Richardson, D.J., Grüner-Nielsen, L., Kakande, J.   +10 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Synergistic Signal Amplification via Weak Value Amplification Effect and Sandwich Structure for Highly Sensitive and Specific Real-Time Detection of CA125

Biosensors
Biomolecule detection is pivotal in disease diagnosis. In this study, we present a novel aptamer–antibody sandwich module integrated with an imaging weak measurement system to enhance the sensitivity and specificity of biomolecule detection.
Bei Wang, Yang Xu, Han Li, Zishuo Song, Tian Guan, Yonghong He   +5 more
doaj   +1 more source

Novel polarization-assisted phase sensitive optical signal processor requiring low nonlinear phase shifts

We demonstrate a new scheme to achieve binary step-like phase response and high phase-sensitive extinction ratio at low powers. Phase-sensitive operation is achieved by polarization filtering phase-locked signal/idler in a degenerate dual-pump vector ...
Horak, P., Hesketh, G., Parmigiani, F., Slavík, R., Petropoulos, P., Richardson, D.J.   +5 more
core  

Reversible Gating of Plasmonic Coupling for Optical Signal Amplification

, 2016
Amplification of optical signals is useful for a wide variety of applications, ranging from data signal transmission to chemical sensing and biomedical diagnostics.
Andrew M. Fales (1308450), Tuan Vo-Dinh (1308447), Christopher G. Khoury (2349265)   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Electrochemical-Signal-Amplification Strategy for an Electrochemiluminescence Immunoassay with g‑C₃N₄ as Tags

, 2018
Signal amplification for electrochemiluminescence (ECL) has conventionally been achieved by employing effective matrixes that can accelerate the electrochemical redox processes or carry more electrochemiluminophores.
Qi Kang (2414137), Dazhong Shen, Guizheng Zou, Yuchen Jin (5856851), Bin Zhang (64682), Guizheng Zou (1412527), Xinli Guo, Dazhong Shen (1605343), Yuchen Jin, Qi Kang, Xinli Guo (5856854), Bin Zhang   +11 more
core   +1 more source