Results 111 to 120 of about 517,159 (303)

Signal amplification in molecular sensing by imprinted polymers. [PDF]

Mikrochim Acta
In the field of sensing, the development of sensors with high sensitivity, accuracy, selectivity, sustainability, simplicity, and low cost remains a key focus.
Chen M, Li H, Xue X, Tan F, Ye L.
europepmc   +2 more sources

Amplification-by-Polymerization in Biosensing for Human Genomic DNA Detection

, 2019
A polymerization reaction was employed as a signal amplification method to realize direct visualization of gender-specific DNA extracted from human blood in a polymerase chain reaction (PCR)-free fashion. Clear distinction between X and Y chromosomes was
Lin He (102807), Peng He (24579), Xinhui Lou (1313469), Susan M. Woody (6589097)   +3 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Integrated double signal amplification systems with ELISA assay for sensitive detection of tylosin in food

Food and Agricultural Immunology
Tylosin (TYL) is a kind of antibiotics which promotes the development of animal husbandry, but it poses potential threats to food safety and human health. Therefore, it is necessary to establish a highly sensitive method for the detection of TYL.
Shan Shan, Xi Lv, Xiaoyue Xiao, Yanmei Huang, Xiaoyu Tong, Weihua Lai, Chengwei Liu, Shuanglong Wang, Daofeng Liu   +8 more
doaj   +1 more source

Identification of bacteria associated with Dinoflagellates (Dinophyceae) Alexandrium spp. using tyramide signal amplification fluorescent in situ hybridization and confocal microscopy

, 2002
In the marine environment, phytoplankton and bacterioplankton can be physically associated. Such association has recently been hypothesized to be involved in the toxicity of the dinoflagellate genus Alexandrium. However, the methods, which have been used
Lennon, J.F., Vaulot, D., Alverca, E., Kennaway, G., Simon, N., Biegala, I.   +5 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Design and Analysis of Micro Signal Detection Circuit for Magnetic Field Detection Utilizing Coil Sensors

Applied Sciences
Eddy current inspection has been extensively employed in non-destructive testing of various conductive materials. The coil probe, as a mainstream sensor in the eddy current detection system, inevitably encounters interference from external signals while ...
Qifan Xu, Sichang Zhang, Siyu Li, Zhe Xu, Shouqi Cao, Meiling Wang   +5 more
doaj   +1 more source

Phase sensitive amplification in a highly nonlinear lead-silicate fibre

We experimentally demonstrate phase-sensitive amplification in a highly nonlinear lead-silicate W-type fibre. A phase-sensitive gain swing of 6dB was observed in a 1.56m sample of the fibre for a total launched power of ...
Shi, J.D., Petropoulos, P., Richardson, D.J., Poletti, F., Kakande, J., Loh, W.H., Ettabib, M.A., Petrovich, M.N., Ponzo, G.M., Jones, L., Slavík, R., Parmigiani, F., Feng, X.   +12 more
core  

Chemosensing via Chemoenzymatic Signal Amplification

, 2015
Specific detection of scarce analytes is extremely important, and many tools such as chemosensors and chemodosimeters have been developed. However, most of classical chemosensors and chemodosimeters are based on stoichiometric molecular recognition or ...
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core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source