Results 91 to 100 of about 6,973,238 (322)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Signal Amplification of Self-Potential Biosensor for Glucose Monitoring

International Journal of Electrochemical Science, 2015
A self-powered electrochemical sensor (SPS) has been designed for sensitive detection of glucose based on the glucose oxidase (GOD)/polyvinyl ferrocene (PVF)/ poly(diallyldimethylammonium chloride) (PDDA -reduced graphene oxide (RGO)/glassy carbon ...
Jingyi Chen, Chao Zhou, Hongyu Liu, Ping Li, Yonghai Song, Fugang Xu   +5 more
doaj   +1 more source

Manipulating Synchronous Optical Signals with a Double $\Lambda $ Atomic Ensemble

, 2004
We analyze a double $\Lambda $ atomic configuration interacting with two signal beams and two control beams. Because of the quantum interference between the two $\Lambda $ channels, the four fields are phase-matched in electromagnetically induced ...
Cerboneschi, Cerboneschi, De-Zhong Cao, Deng, Fleischhauer, Fleischhauer, Fleischhauer, Harris, Harris, Harris, Jain, Kaige Wang, Korsunsky, Korsunsky, Kozhekin, Liu, Lukin, Lukin, Matsko, Merriam, Phillips, Raczynski, Taichenachev, Wang, Wang, Wu, Zhuan Li   +26 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Polarization dependent Brillouin gain in randomly birefringent fibers

, 2009
An extensive study of the alignment between the pump, the signal and the polarization dependent gain (PDG) vectors in stimulated Brillouin amplification in randomly birefringent fibers is realized by numerically integrating the equations governing the ...
Palmieri, Luca, Santagiustina, Marco, Ursini, Leonora   +2 more
core   +1 more source

CRISPR/Cas13a Signal Amplification Linked Immunosorbent Assay for Femtomolar Protein Detection.

Analytical Chemistry, 2019
The enzyme-linked immunosorbent assay (ELISA) is a basic technique used in analytical and clinical investigations. However, conventional ELISA is still not sensitive enough to detect ultra-low concentrations of biomarkers for the early diagnosis of ...
Qian Chen, Tian Tian, Erhu Xiong, Po Wang, Xiaoming Zhou   +4 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing

International Journal of Nanomedicine, 2016
Omary Mzava,1 Zehra Tas,1 Kutay İçöz1,2 1BioMINDS (Bio Micro/Nano Devices and Sensors) Laboratory, Department of Electrical and Electronics Engineering, 2Bioengineering Department, Abdullah Gül University, Kayseri, Turkey Abstract: We ...
Mzava O, Taş Z, İçöz K
doaj