Results 81 to 90 of about 6,973,238 (322)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A General Biosensing Strategy Based on Cascade Amplification for Enhanced HIV Detection Sensitivity

BME Frontiers
Objective: Accurate and rapid detection of disease biomarkers is critical for early diagnosis, timely intervention, and effective disease management. Impact Statement: This strategy is exemplified through the development of 2 biosensors for detecting HIV-
Yirui Zhang, Jieyu Yan, Wangheng Hou, Qian Gao, Tao Zhang, Yan Gao, Jingwen Li, Kun Han   +7 more
doaj   +1 more source

Gold Nanoparticles Used as Protein Scavengers Enhance Surface Plasmon Resonance Signal

Sensors, 2017
Although several researchers had reported on methodologies for surface plasmon resonance (SPR) signal amplification based on the use of nanoparticles (NPs), the majority addressed the sandwich technique and low protein concentration.
Erenildo Ferreira de Macedo, Daniela Maria Ducatti Formaggio, Nivia Salles Santos, Dayane Batista Tada   +3 more
doaj   +1 more source

Cathode Ray Tube Display with Cancellation of Electric Field Emissions [PDF]

, 1994
A cathode ray tube display having reduced electric field emissions comprising a cathode ray tube 100, an element 200 for detecting modulations in the final anode voltage of the CRT, the signal not being directly dependent on the deflection driving means ...
Beeteson, J.S., Jackson, F.S., Knox, A., Leaver, D.   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

LC-oscillator with automatic stabilized amplitude via bias current control [PDF]

, 1974
A stable excitation supply for measurement transducers is described. It consists of a single-transistor oscillator with a coil connected to the collector and a capacitor connected from the collector to the emitter.
Hamlet, J. F.
core   +1 more source

Reduction of quantum noise in optical interferometers using squeezed light

, 2010
We study the photon counting noise in optical interferometers used for gravitational wave detection. In order to reduce quantum noise a squeezed vacuum state is injected into the usually unused input port. Here, we specifically investigate the so called `
B. Yurke, C. M. Caves, D. Scholz, J. Wei, M. O. Scully, M. Weyrauch, O. Assaf, R. A. Campos, R. Barak, V. G. Voronov, V. G. Voronov   +10 more
core   +1 more source

Direct quantification of cancerous exosomes via surface plasmon resonance with dual gold nanoparticle-assisted signal amplification.

Biosensors & bioelectronics, 2019
Sensitive detection of cancerous exosomes is critical to early diseases diagnosis and prognosis. Herein, a sensitive aptasensor was demonstrated for exosomes detection by surface plasmon resonance (SPR) with dual gold nanoparticle (AuNP)-assisted signal ...
Qing Wang, Liyuan Zou, Xiaohai Yang, Xiaofeng Liu, Wenyan Nie, Yan Zheng, Q. Cheng, Kemin Wang   +7 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Silica nanoparticles as a carrier for signal amplification

Reviews in Analytical Chemistry, 2012
Owing to the small size, high surface-to-volume ratio, and good biocompatibility, silica nanoparticles (SiNPs) have become the normally used carrier for biomolecule immobilization.
Wei Wei, Wei Min, Liu Songqin
doaj   +1 more source