Results 71 to 80 of about 6,973,238 (322)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Thermodynamic and Kinetic Analysis of Sensitivity Amplification in Biological Signal Transduction [PDF]

, 2002
Based on a thermodynamic analysis of the kinetic model for the protein phosphorylation-dephosphorylation cycle, we study the ATP (or GTP) energy utilization of this ubiquitous biological signal transduction process.
Bourne, Ferrell, Goldbeter, Goldbeter, Gresser, Hartwell, Hill, Hill, Hopfield, Hopfield, Huang, Koshland, Koshland, Krebs, Kushmerick, Li, McKeithan, Poland, Qian, Qian, Shacter, Stadtman, Stryer, Wyman   +23 more
core   +5 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

All optical Amplification in Metallic Subwavelength Linear Waveguides

, 2013
Proposed all optical amplification scenario is based on the properties of light propagation in two coupled subwavelength metallic slab waveguides where for particular choice of waveguide parameters two propagating (symmetric) and non-propagating ...
Khomeriki, Ramaz, Leon, Jerome
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Signal amplification in a nanomechanical Duffing resonator via stochastic resonance

, 2006
We experimentally study stochastic resonance in a nonlinear bistable nanomechanical resonator. The device consists of a PdAu doubly clamped beam serving as a nanomechanical resonator excited capacitively by an adjacent gate electrode and its vibrations ...
Almog, Ronen, Buks, Eyal, Shtempluck, Oleg, Zaitsev, Stav   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

POSA for fast, amplified and multiplexed protein imaging

Nature Communications
Fluorescent π-conjugated polymers (FCPs) are known for their superior brightness but are still unavailable for highly multiplexed molecular imaging in single cells as they are hydrophobic and lack targeting capability toward biomolecules.
Wenkang Zhang, Hengfeng Jiang, Liang Han, Jie Liu, Jie Wang, Feng He, Leilei Tian   +6 more
doaj   +1 more source

SURVEY OF HYBRID EDFA/RAMAN IN C AND L BANDS

Revista Ingeniería, Matemáticas y Ciencias de la Información, 2017
Optical amplifiers have had a breakthrough in recent years. Initially, amplification of optical signals was performed passing the optical signal to the electrical domain, then the amplified signal back again to the optical domain.
JUAN DAVID BONILLA
doaj   +1 more source

Noiseless amplification of weak coherent fields without external energy

, 2013
According to the fundamental laws of quantum optics, noise is necessarily added to the system when one tries to clone or amplify a quantum state. However, it has recently been shown that the quantum noise related to the operation of a linear phase ...
Häyrynen, Teppo, Oksanen, Jani, Partanen, Mikko, Tulkki, Jukka   +3 more
core   +1 more source