Results 71 to 80 of about 517,159 (303)

Gold Nanoparticles Used as Protein Scavengers Enhance Surface Plasmon Resonance Signal

open access: yesSensors, 2017
Although several researchers had reported on methodologies for surface plasmon resonance (SPR) signal amplification based on the use of nanoparticles (NPs), the majority addressed the sandwich technique and low protein concentration.
Erenildo Ferreira de Macedo   +3 more
doaj   +1 more source

Self‐Propagating Amplification Reactions for Molecular Detection and Signal Amplification: Advantages, Pitfalls, and Challenges

open access: yes, 2018
Self‐propagating cascade reactions are a recent development for chemosensing protocols. These cascade reactions, in principle, offer low limits of detection by virtue of exponential signal amplification and are initiated by a specific, preplanned ...
Phillips, Scott T.   +7 more
core   +1 more source

Amplification-Free Ratiometric Electrochemical Aptasensor for Point-of-Care Detection of Therapeutic Monoclonal Antibodies

open access: yes, 2023
The rapid quantification of therapeutic monoclonal antibodies (mAbs) is of great significance to their pharmacokinetics/pharmacodynamics (PK/PD) research and the personalized medication for disease treatment.
Jianwen Wan (12901530)   +21 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Silica nanoparticles as a carrier for signal amplification

open access: yesReviews in Analytical Chemistry, 2012
Owing to the small size, high surface-to-volume ratio, and good biocompatibility, silica nanoparticles (SiNPs) have become the normally used carrier for biomolecule immobilization.
Wei Wei, Wei Min, Liu Songqin
doaj   +1 more source

Signal Amplification of Self-Potential Biosensor for Glucose Monitoring

open access: yesInternational Journal of Electrochemical Science, 2015
A self-powered electrochemical sensor (SPS) has been designed for sensitive detection of glucose based on the glucose oxidase (GOD)/polyvinyl ferrocene (PVF)/ poly(diallyldimethylammonium chloride) (PDDA -reduced graphene oxide (RGO)/glassy carbon ...
Jingyi Chen   +5 more
doaj   +1 more source

A fast large-signal model for coupled-cavity TWTS. [PDF]

open access: yes, 1988
A fast and accurate one-dimensional large-signal model for coupled-cavity TWTs has been developed that can be used interactively for the optimization of a TWT design. Different modeling techniques for enhancing the speed of the large-signal model with no
Carter, Richard G., Srivastava, V.
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Enzymatic Signal Amplification of Molecular Beacons for Sensitive DNA Detection

open access: yes, 2008
Molecular beacons represent a new family of fluorescent probes for nucleic acids, and have found broad applications in recent years due to their unique advantages over traditional probes.
Lee, Benjamin Yi-Hung   +7 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

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