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Ionic Signal Amplification of DNA in a Nanopore
Small Methods, 2022AbstractIonic signal amplification is a key challenge for single‐molecule analyses by solid‐state nanopore sensing. Here, a permittivity gradient approach for amplifying ionic blockade characteristics of DNA in a nanofluidic channel is reported. The transmembrane ionic current response is found to change substantially through modifying the liquid ...
Makusu Tsutsui +3 more
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Amplification of Signaling Events in Bacteria
Science's STKE, 2002Bacteria respond to extremely shallow chemical gradients by modifying their motility in a process called chemotaxis. This chemotactic response is characterized by high sensitivity to small concentration differences, which extends over a large range of concentrations.
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DNAzyme amplification of molecular beacon signal
Talanta, 2005This paper reports an improved catalytic molecular beacon. Addition of the target oligonucleotide activates a DNA enzyme (DNAzyme), which, in turn, activates multiple copies of molecular beacons (MB) and gives rise to a strong fluorescence signal.
Ye, Tian, Chengde, Mao
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Signal Amplification for Imaging Mass Cytometry
Bioconjugate Chemistry, 2019An enzyme-catalyzed reporter deposition stain has been developed for Imaging Mass Cytometry (IMC). The reagent consists of an alkaline phosphatase substrate tethered to a tellurophene which serves as reporter group for mass cytometry. Upon phosphate hydrolysis, a quinone methide is released which covalently labels local nucleophiles. This strategy is a
Rahul Rana +3 more
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Signal Amplification for Nanobiosensing
2011One of the major goals in developing novel biological assay methods for the detection of biomolecules and DNA hybridization is achieving high sensitivity. The need for ultrasensitive bioassays is of major importance in view of the growing trend toward miniaturized assays.
Huangxian Ju, Xueji Zhang, Joseph Wang
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Tyramide Signal Amplification for Immunofluorescent Enhancement
2015Enzyme-linked signal amplification is a key technique used to enhance the immunohistochemical detection of protein, mRNA, and other molecular species. Tyramide signal amplification (TSA) is based on a catalytic reporter deposit in close vicinity to the epitope of interest.
Lauren, Faget, Thomas S, Hnasko
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Sensitivity and Specificity Amplification in Signal Transduction
Cell Biochemistry and Biophysics, 2003Intracellular signal transduction pathways transmit signals from the cell surface to various intracellular destinations, such as cytoskeleton and nucleus through a cascade of protein-protein interactions and activation events, leading to phenotypic changes such as cell proliferation, differentiation, and death.
Guangpu, Li, Hong, Qian
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1977
The devices and circuits described so far have not allowed direct connection of input signals from, say, a microphone or an oscillator, nor have they allowed direct connection to, say, another amplifier or measuring instrument. So that a complete electronic circuit may be constructed using a transistor or triode, additional components must be added for
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The devices and circuits described so far have not allowed direct connection of input signals from, say, a microphone or an oscillator, nor have they allowed direct connection to, say, another amplifier or measuring instrument. So that a complete electronic circuit may be constructed using a transistor or triode, additional components must be added for
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2016
Signal amplification methods were initially designed as an alternative to the target amplification technologies such as polymerase chain reaction (PCR) so as to minimize the possibility of contamination by target amplification products. Unlike target amplification, signal amplification methods (as defined herein) do not rely on enzymes for the ...
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Signal amplification methods were initially designed as an alternative to the target amplification technologies such as polymerase chain reaction (PCR) so as to minimize the possibility of contamination by target amplification products. Unlike target amplification, signal amplification methods (as defined herein) do not rely on enzymes for the ...
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Signal Amplification Technologies
2012The introduction of target nucleic acid amplification technologies, such as polymerase chain reaction (PCR), nucleic acid sequence-based amplification (NASBA), and strand displacement amplification (SDA), was accompanied by a plethora of technology patents.
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