Results 1 to 10 of about 1,096,363 (351)
Signal transduction with a swing [PDF]
Nature Chemistry, 2021 The continuous monitoring of proteins is a current challenge in medical diagnostics. A new electrochemical approach aiming to address this has been described. The method uses antibodies as a recognition element to achieve the real-time measurement of proteins in saliva in the mouth.
Kevin J. Cash, Kevin W. Plaxco
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Artificial Signal Transduction [PDF]
ChemistryOpen, 2020 AbstractCommunication between and inside cells as well as their response to external stimuli relies on elaborated systems of signal transduction. They all require a directional transmission across membranes, often realized by primary messenger docking onto external receptor units and subsequent internalization of the signal in form of a released second
Robert Bekus, Thomas Schrader
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Role of relaxation time scale in noisy signal transduction [PDF]
, 2014 Intracellular fluctuations, mainly triggered by gene expression, are an inevitable phenomenon observed in living cells. It influences generation of phenotypic diversity in genetically identical cells.
Banik, Suman K. +2 more
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AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Nature Communications, 2022 Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng +8 more
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Epigenetics of cancer drug resistance
Academia Biology, 2023 One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells.
Sayandeep Mukherjee +4 more
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Scientific Reports, 2021 Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been
Yohei Tsukada +7 more
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Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
Scientific Reports, 2021 The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu +3 more
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EMBO Molecular Medicine, 2023 SARS‐CoV‐2 may directly and indirectly damage lung tissue and other host organs, but there are few system‐wide, untargeted studies of these effects on the human body.
Lisa Schweizer +11 more
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The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma
Cell Death and Disease, 2022 Cholangiocarcinoma (CCA) is an epithelial malignancy with a dismal prognosis owing to limited treatment options. Here, we identified several compound candidates against CCA using a high-throughput drug screen with approved or emerging oncology drugs ...
Yuanyuan Shi +10 more
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Journal of Experimental & Clinical Cancer Research, 2019 Background Despite the increasing progress in targeted and immune based-directed therapies for other solid organ malignancies, currently there is no targeted therapy available for TNBCs.
Murugan Kalimutho +9 more
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