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Novel Signal Transduction Pathway Utilized by Extracellular HSP70 [PDF]
Journal of Biological Chemistry, 2002 Recent studies have initiated a paradigm shift in the understanding of the function of heat shock proteins (HSP). It is now clear that HSP can and do exit mammalian cells, interact with cells of the immune system, and exert immunoregulatory effects.
Alexzander Asea +7 more
openalex +2 more sources
Targeting PI3K/Akt signal transduction for cancer therapy
Signal Transduction and Targeted Therapy, 2021 The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence and progression of tumors.
Yan He +6 more
semanticscholar +1 more source
Targeting TGF-β signal transduction for fibrosis and cancer therapy
Molecular Cancer, 2022 Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis.
Dandan Peng +4 more
semanticscholar +1 more source
AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Nature Communications, 2022 Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng +8 more
doaj +1 more source
Targeting TGFβ signal transduction for cancer therapy
Signal Transduction and Targeted Therapy, 2021 Transforming growth factor-β (TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis. Dysregulation
Sijia Liu, Jiang Ren, P. ten Dijke
semanticscholar +1 more source
Epigenetics of cancer drug resistance
Academia Biology, 2023 One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells.
Sayandeep Mukherjee +4 more
doaj +1 more source
Scientific Reports, 2021 Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been
Yohei Tsukada +7 more
doaj +1 more source
Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
Scientific Reports, 2021 The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu +3 more
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EMBO Molecular Medicine, 2023 SARS‐CoV‐2 may directly and indirectly damage lung tissue and other host organs, but there are few system‐wide, untargeted studies of these effects on the human body.
Lisa Schweizer +11 more
doaj +1 more source
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
Molecular Cancer, 2023 The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression.
Antonino Glaviano +26 more
semanticscholar +1 more source