, 2020 Atomic vapors offer many opportunities for manipulating electromagnetic signals across a broad range of the electromagnetic spectrum. Here, a microwave signal with an audio-frequency modulation encodes information in an optical signal by exploiting an ...
Davis, J. P. +5 more
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Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kB signaling pathway [PDF]
, 2006 Mathematical modelling offers a variety of useful techniques to help in understanding the intrinsic behaviour of complex signal transduction networks. From the system engineering point of view, the dynamics of metabolic and signal transduction models can
Broomhead, David S. +5 more
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Optimal Phosphorylation Step Number of Intracellular Signal Transduction Pathway [PDF]
, 2005 Eukaryotic cells use signal transduction network to respond in specific ways to external signals from their environment. Several signal transduction pathway are composed of multi-step chemical reactions.
Nakabayashi, J., Sasaki, A.
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Model simplification of signal transduction pathway networks via a hybrid inference strategy [PDF]
, 2008 A full-scale mathematical model of cellular networks normally involves a large number of variables and parameters. How to effectively develop manageable and reliable models is crucial for effective computation, analysis and design of such systems.
Asthagiri +26 more
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Approximations and their consequences for dynamic modelling of signal transduction pathways [PDF]
, 2007 Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins.
Asthagiri +49 more
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Non-equilibrium phase transitions in biomolecular signal transduction
, 2011 We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of
A. J. Ninfa +13 more
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High-speed single-molecule imaging reveals signal transduction by induced transbilayer raft phases [PDF]
, 2020 Ikuko Koyama‐Honda +7 more
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Scientific Reports, 2017 In addition to mediating regulation of endogenous gene expression, RNA interference (RNAi) in plants and invertebrates plays a crucial role in defense against viruses via virus-specific siRNAs.
Niels Wynant +2 more
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LNK (SH2B3): paradoxical effects in ovarian cancer. [PDF]
, 2015 LNK (SH2B3) is an adaptor protein studied extensively in normal and malignant hematopoietic cells. In these cells, it downregulates activated tyrosine kinases at the cell surface resulting in an antiproliferative effect. To date, no studies have examined
Chien, W +16 more
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DRASTIC—INSIGHTS:querying information in a plant gene expression database [PDF]
, 2005 DRASTIC––Database Resource for the Analysis of Signal Transduction In Cells (http://www.drastic.org.uk/) has been created as a first step towards a data-based approach for constructing signal transduction pathways.
Ball, Leslie D. +5 more
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