Results 1 to 10 of about 653,896 (100)

AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics

Nature Communications, 2022
Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng, Xie-Xuan Zhou, Sander Willems, Constantin Ammar, Maria Wahle, Isabell Bludau, Eugenia Voytik, Maximillian T. Strauss, Matthias Mann   +8 more
doaj   +1 more source

Epigenetics of cancer drug resistance

Academia Biology, 2023
One of the major causes due to cancer-related death is metastasis. The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells.
Sayandeep Mukherjee, Ronit Dey, Subhabrata Guha, Nabendu Murmu, Gaurav Das   +4 more
doaj   +1 more source

An in vivo model allowing continuous observation of human vascular formation in the same animal over time

Scientific Reports, 2021
Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been
Yohei Tsukada, Fumitaka Muramatsu, Yumiko Hayashi, Chiaki Inagaki, Hang Su, Tomohiro Iba, Hiroyasu Kidoya, Nobuyuki Takakura   +7 more
doaj   +1 more source

Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization

Scientific Reports, 2021
The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu, Yumiko Hayashi, Hiroyasu Kidoya, Nobuyuki Takakura   +3 more
doaj   +1 more source

Quantitative multiorgan proteomics of fatal COVID‐19 uncovers tissue‐specific effects beyond inflammation

EMBO Molecular Medicine, 2023
SARS‐CoV‐2 may directly and indirectly damage lung tissue and other host organs, but there are few system‐wide, untargeted studies of these effects on the human body.
Lisa Schweizer, Tina Schaller, Maximilian Zwiebel, Özge Karayel, Johannes Bruno Müller‐Reif, Wen‐Feng Zeng, Sebastian Dintner, Thierry M Nordmann, Klaus Hirschbühl, Bruno Märkl, Rainer Claus, Matthias Mann   +11 more
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The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma

Cell Death and Disease, 2022
Cholangiocarcinoma (CCA) is an epithelial malignancy with a dismal prognosis owing to limited treatment options. Here, we identified several compound candidates against CCA using a high-throughput drug screen with approved or emerging oncology drugs ...
Yuanyuan Shi, Xiaowen Cui, Tianyi Jiang, Yufei Pan, Yunkai Lin, Xiaofan Feng, Zhiwen Ding, Chun Yang, Yexiong Tan, Hongyang Wang, Liwei Dong   +10 more
doaj   +1 more source

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Journal of Experimental & Clinical Cancer Research, 2019
Background Despite the increasing progress in targeted and immune based-directed therapies for other solid organ malignancies, currently there is no targeted therapy available for TNBCs.
Murugan Kalimutho, Debottam Sinha, Deepak Mittal, Sriganesh Srihari, Devathri Nanayakkara, Shagufta Shafique, Prahlad Raninga, Purba Nag, Kate Parsons, Kum Kum Khanna   +9 more
doaj   +1 more source

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

Nature Communications, 2021
Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling ...
Fynn M. Hansen, Maria C. Tanzer, Franziska Brüning, Isabell Bludau, Che Stafford, Brenda A. Schulman, Maria S. Robles, Ozge Karayel, Matthias Mann   +8 more
doaj   +1 more source

Enhanced glucose metabolism through activation of HIF-1α covers the energy demand in a rat embryonic heart primordium after heartbeat initiation

Scientific Reports, 2022
The initiation of heartbeat is an essential step in cardiogenesis in the heart primordium, but it remains unclear how intracellular metabolism responds to increased energy demands after heartbeat initiation.
Tatsuya Sato, Nobutoshi Ichise, Takeshi Kobayashi, Hiroyori Fusagawa, Hiroya Yamazaki, Taiki Kudo, Noritsugu Tohse   +6 more
doaj   +1 more source

Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine

Inflammation and Regeneration, 2019
Background During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels.
Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi, Nobuyuki Takakura   +5 more
doaj   +1 more source