Results 241 to 250 of about 5,103,566 (350)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors. [PDF]

Elife
Xiong F, Tentner AR, Nandagopal S, Hiscock TW, Huang P, Tsung-Megason SG.   +5 more
europepmc   +1 more source

Multi-objective Optimization in Traffic Signal Control

, 2019
Phuong Nguyen
openalex   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines

Haematologica, 2013
Haidar Akl, Ilse Vandecaetsbeek, Giovanni Monaco, Alexandre Kauskot, Tomas Luyten, Kirsten Welkenhuyzen, Marc Hoylaerts, Humbert De Smedt, Jan B. Parys, Geert Bultynck   +9 more
doaj   +1 more source

Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in <i>Panax ginseng</i>. [PDF]

Biomolecules
Kim KH, Yoo BC.
europepmc   +1 more source

Depression classification with MDD (Major Depressive Disorder) using signal processing and machine learning

, 2020
Shahriar Saleque, Gul-A-Zannat Spriha, Rasheeq Ishraq Kamal, Rafia Tabassum Khan   +3 more
openalex   +1 more source

Immunoreceptor Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Rheostats, not switches: Nuclear receptor dosage tunes somatic-to-iPSC reprogramming. [PDF]

Stem Cell Reports
Chronis C.
europepmc   +1 more source