Results 211 to 220 of about 1,476,364 (294)

SPP1 regulates tumor progression through modulation of signaling pathways and the tumor microenvironment. [PDF]

Discov Oncol
Feng Y, Shao X, Xu ZF, Liu P, Wu H, Cheng Y, Qi M, Meng H, Zhang B, Jian FZ, Chen Z, Duan W.   +11 more
europepmc   +1 more source

Role of estrogen in lung cancer based on the estrogen receptor-epithelial mesenchymal transduction signaling pathways

, 2015
Xiaozhen Zhao, Yu Liu, Lijuan Zhou, Xiaoyuan Yang, Zhongqi Wang, Zhonghua Wu   +5 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies. [PDF]

Bone Res
de Molon RS, Vernal R, Oliveira GE, Steffens JP, Ervolino E, Theodoro LH, van den Beucken JJJP, Tetradis S.   +7 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RIPK1 signaling pathways: implications for autoimmune and neuroinflammatory diseases. [PDF]

Front Immunol
Pajulas A, Sims JT, Hanson EP, Vendel AC.   +3 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The Regulatory Role of m⁶A Modification in the Function and Signaling Pathways of Animal Stem Cells. [PDF]

Cells
Yang X, Xu Y, Zhu S, Wang M, Cao H, Lu L.   +5 more
europepmc   +1 more source

Genetic and Functional Characterization of AMH Signaling in Zebrafish - Evidence for Roles of Amh-Bmpr2a-Bmpr1bb Pathway in Controlling Gonadal Homeostasis

Yiming Yue, Zeng Chu, Xin Zhang, Chao Bian, Zhiwei Zhang, Kun Wu, Wei-Ting Chen, Xianqing Zhou, Ling Lu, Nana Ai, Wei Ge   +10 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source