Results 211 to 220 of about 2,211,530 (330)

Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways.

, 1990
Bradford C. Berk, Mark B. Taubman, Edward J. Cragoe, John W. Fenton, Kathy K. Griendling   +4 more
openalex   +1 more source

The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression [PDF]

, 1991

openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Transcriptional profiling identification of inflammatory signaling pathways in ulcerative colitis. [PDF]

PLoS One
Misaghian S, Jafri MS.
europepmc   +1 more source

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

, 1994
Kazuyoshi Yonezawa, A Ando, Yasushi Kaburagi, Ritsuko Yamamoto‐Honda, Tadahiro Kitamura, Kenta Hara, Masato Nakafuku, Yoshinori Okabayashi, Takashi Kadowaki, Y Kaziro   +9 more
openalex   +1 more source

Potentiation of the erythropoietin response by dimethyl sulfoxide priming of erythroleukemia cells: evidence for interaction of two signaling pathways [PDF]

, 1990
Yijuang Chern, Shuji Yonekura, AJ Sytkowski   +2 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

The multifaceted impact of physical exercise on FoxO signaling pathways. [PDF]

Front Cell Dev Biol
Liu W, Meng P, Li Z, Shen Y, Meng X, Jin S, Hu M.   +6 more
europepmc   +1 more source

Inhibitory control of prolactin and Pit-1 gene promoters by dopamine. Dual signaling pathways required for D2 receptor-regulated expression of the prolactin gene.

, 1991
Harry P. Elsholtz, Andrew M. Lew, Paul R. Albert, V.C. Sundmark   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source