Results 171 to 180 of about 2,656,427 (351)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cerium Oxide Nanoparticles Protect Cortical Astrocytes from Oxygen-Glucose Deprivation through Activation of the Ca²⁺ Signaling System. [PDF]

Int J Mol Sci, 2023
Varlamova EG, Varlamova EG, Baryshev AS, Gudkov SV, Babenko VA, Plotnikov EY, Turovsky EA.   +6 more
europepmc   +1 more source

Advanced tensor based signal processing techniques for wireless communication systems and biomedical signal processing [PDF]

, 2020
Kristina Naskovska
openalex  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification of an allatostatin C signaling system in mollusc Aplysia. [PDF]

Sci Rep, 2022
Jiang HM, Yang Z, Xue YY, Wang HY, Guo SQ, Xu JP, Li YD, Fu P, Ding XY, Yu K, Liu WJ, Zhang G, Wang J, Zhou HB, Susswein AJ, Jing J.   +15 more
europepmc   +1 more source

Communicating with noisy signals: lessons learned from the mammalian visual system

, 2015
Joel Zylberberg
openalex   +1 more source

Transmembrane signalling systems.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1984
The three major strategies for transmembrane signalling at the plasma membrane level involve either second messengers, ion channels or receptor-mediated endocytosis. Two second-messenger types of transmembrane signalling systems have been analyzed: the adenylate cyclase and protein kinase C systems. Both are triggered by a variety of biological signals
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A Phylogenetic Perspective on the Evolutionary Patterns of the Animal Interleukin-10 Signaling System. [PDF]

Genes (Basel)
Tang L, Zhou Z, Wang W, Li D, Hao T, Chen Y.   +5 more
europepmc   +1 more source

G protein-coupled estrogen receptor 1 regulates renal endothelin-1 signaling system in a sex-specific manner. [PDF]

Front Physiol, 2023
Guthrie GL, Almutlaq RN, Sugahara S, Butt MK, Brooks CR, Pollock DM, Gohar EY.   +6 more
europepmc   +1 more source