Results 151 to 160 of about 1,678,713 (260)

The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein. [PDF]

Cell Mol Life Sci
Będzińska A, Łasut-Szyszka B, Krześniak M, Gdowicz-Kłosok A, Rusin M.   +4 more
europepmc   +1 more source

A Complete Endocannabinoid Signaling System Modulates Synaptic Transmission between Human Induced Pluripotent Stem Cell-Derived Neurons. [PDF]

Mol Pharmacol, 2023
Asher MJ, McMullan HM, Dong A, Li Y, Thayer SA.   +4 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Discovery and functional characterization of a bombesin-type neuropeptide signaling system in an invertebrate. [PDF]

Proc Natl Acad Sci U S A
Huang W, Zhong X, Zampronio CG, Bottrill AR, Jones KGE, Tinoco AB, Guo L, Egertová M, Mirabeau O, Elphick MR.   +9 more
europepmc   +1 more source

The Interplay Among HIV, LINE-1, and the Interferon Signaling System. [PDF]

Front Immunol, 2021
Zhao X, Zhao Y, Du J, Gao P, Zhao K.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Roles of the FGF-FGFR Signaling System in Cancer Development and Inflammation. [PDF]

Cells, 2021
Wiedlocha A, Haugsten EM, Zakrzewska M.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Ovarian tachykinin signaling system induces the growth of secondary follicles during the gonadotropin-independent process. [PDF]

J Biol Chem
Kawada T, Aoyama M, Matsubara S, Osugi T, Sakai T, Kirimoto S, Nakaoka S, Sugiura Y, Yasuda K, Satake H.   +9 more
europepmc   +1 more source

High-Level Expression of Cell-Surface Signaling System Hxu Enhances Pseudomonas aeruginosa Bloodstream Infection. [PDF]

Infect Immun, 2022
Yang F, Zhou Y, Chen P, Cai Z, Yue Z, Jin Y, Cheng Z, Wu W, Yang L, Ha UH, Bai F.   +10 more
europepmc   +1 more source